Terahertz probe for real time in vivo skin hydration evaluation  

作　　者：Arturo I.Hernandez-Serrano Xuefei Ding Jacob Young Goncalo Costa Anubhav Dogra Joseph Hardwicke Emma Pickwell-MacPherson 

机构地区：[1]University of Warwick,Department of Physics,Coventry,United Kingdom [2]Warwick Medical School,University of Warwick,Coventry,United Kingdom [3]Institute of Applied and Translational Technologies in Surgery,University Hospitals Coventry and Warwickshire NHS Trust,Coventry,United Kingdom

出　　处：《Advanced Photonics Nexus》2024年第1期93-103,共11页先进光子学通讯（英文）

基　　金：support from the Engineering and Physical Sciences Research Council (EPSRC) (Grant Nos.EP/S021442/1 and EP/V047914/1);Cancer Research UK,the Royal Society (Wolfson Merit Award-EPM);the Health GRP at Warwick University.

摘　　要：This study introduces a handheld terahertz(THz)scanner designed to quantitatively evaluate human skin hydration levels and thickness.This device,through the incorporation of force sensors,demonstrates enhanced repeatability and accuracy over traditional fixed THz systems.The scanner was evaluated in the largest THz skin study to date,assessing 314 volunteers,successfully differentiating between individuals with dry skin and hydrated skin using a numerical stratified skin model.The scanner measures and displays skin hydration dynamics within a quarter of a second,indicating its potential for real-time,noninvasive examinations,opening up opportunities for in vivo and ex vivo diagnosis during patient consultations.Furthermore,the portability and ease of use of our scanner enable its widespread application for in vivo and ex vivo diagnosis during patient consultations,potentially allowing in situ biopsy evaluation and elimination of histopathology processing wait times,thereby improving patient outcomes by facilitating simultaneous tumor diagnosis and removal.

关 键 词：TERAHERTZ real time stratum corneum HYDRATION in vivo diagnosis noninvasive examination 

分 类 号：TN9[电子电信—信息与通信工程]