Mechanical properties modulation and biological applications of DNA hydrogels  

作　　者：Yiliu Wang Yu Zhang Qi Zhang Xia Li Qinglong Yan Ying Zhu 

机构地区：[1]Division of Physical Biology,CAS Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China [2]Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology,School of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252000,China [3]Institute of Materiobiology,College of Sciences,Shanghai University,Shanghai 200444,China [4]Jiaxing Key Laboratory of Biosemiconductors,Xiangfu Laboratory,Jiashan 314102,China [5]The Interdisciplinary Research Center,Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China [6]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Advanced Sensor and Energy Materials》2024年第3期50-60,共11页先进传感器与能源材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2023YFB3208204);the National Natural Science Foundation of China(12305400,12105352);the Natural Science Foundation of Shanghai,China(22ZR1470600);the Natural Science Foundation of Shandong Province(ZR2019MB068,ZR2022MB012,ZR2021QE167);the Xiangfu Lab Research Project(XF012022E0100).

摘　　要：DNA hydrogels are three-dimensional polymer networks constructed using DNA as the structural building block.Due to the tight binding between hydrophilic groups on DNA chains and water molecules,they exhibit outstanding plasticity and fluid thermodynamic properties,making them one of the best choices for mimicking natural biological tissues.By controlling the backbone building blocks,gelation conditions,and cross-linking methods of DNA hydrogels,hydrogels with different mechanical strengths can be obtained,thus expanding their applications in the field of biology.This review first introduces the relationship between the mechanical properties of DNA hydrogels and their structure,elucidates the approaches and strategies for mechanical property modulation,and focuses on the scheme of controllable design to modulate the mechanical properties of DNA hydrogels for applications in biosensing,cellular function regulation,and bone tissue engineering.Furthermore,this review outlines the future development directions and challenges faced in the mechanical property modulation of DNA hydrogels,providing useful information for the precise design of DNA hydrogels for biological research.

关 键 词：DNA hydrogel Mechanical property modulation BIOSENSING Biological function regulation 

分 类 号：O63[理学—高分子化学]