四逆散及其单味药有效成分抗抑郁的研究进展  

Research Progress on Sini Powder(四逆散)and Its Single Active Ingredient with Antidepressant Effects

作　　者：金霞霞 董文迪 闫咏梅 周锋 高桃[4] 常凯乐 JIN Xiaxia;DONG Wendi;YAN Yongmei;ZHOU Feng;GAO Tao;CHANG Kaile(Mational Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Foshan Clinical Medical College,Guangzhou University of Chinese Medicine,Foshan 511400,Guangdong,China;Department of Encephalopathy,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China;Department of Acupuncture and Moxibustion,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]中国中医科学院中药资源中心,北京100700 [2]广州中医药大学佛山临床医学院,广东佛山528000 [3]陕西中医药大学附属医院,陕西咸阳712000 [4]陕西中医药大学,陕西咸阳712046

出　　处：《中华中医药学刊》2024年第12期29-34,I0032,共7页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81973843);国家岐黄学者支持项目(国中医药人教函〔2022〕6号);张学文国医大师学术经验传承创新研究项目(陕西省中医药管理局)。

摘　　要：抑郁障碍是一种以情绪低落、丧失愉悦感为主要特征,并伴有认知和行为及植物神经症状的一种精神障碍类疾病,具有高患病率、高致残率、高自杀率、高复发率的特点,严重影响着患者的生活质量,是临床治疗难点之一。四逆散是临床疏肝的经典方,由柴胡、白芍、枳实和炙甘草4味药按1∶1∶1∶1等比例组成,具有透邪解郁,疏肝理脾,和解表里的功效;广泛地应用于因肝郁气滞引起的各种疾病,疗效确切。研究发现,四逆散可通过调控神经环路、神经递质、免疫炎症反应以及离子转运等多靶点达到抗抑郁的目的。对四逆散及单味药有效成分抗抑郁的作用机制及其临床应用进行归纳总结,旨在为抑郁障碍的中医药治疗提供借鉴。Depressive disorder is a kind of mental disorder characterized by low mood and loss of pleasure,accompanied by cognitive,behavioral and autonomic symptoms.It has the characteristics of high prevalence,high disability rate,high suicide rate and high recurrence rate,which seriously affects the quality of life of patients and is one of the difficulties in clinical treatment.Sini Powder(四逆散)is a classic prescription for soothing liver.It is composed of Chanhai(Bupleuri Radix),Baishao(Paeoniae Radix Alba),Zhishi(Aurantii Fructus Immaturus)and Zhigancao(Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle)at an equal ratio of 1∶1∶1∶1.It is widely used in various diseases caused by liver depression and Qi stagnation,and the curative effect is exact.Studies have found that Sini Powder can achieve the purpose of antidepressant by regulating multiple targets such as neural circuit,neurotransmitter,immune inflammatory response and ion transport.This article summarized the antidepressant mechanism and clinical application of Sini Powder and its active ingredients,aiming to provide reference for the treatment of de-pressive disorder with traditional Chinese medicine.

关 键 词：四逆散 抑郁障碍 机制 活性成分 抗抑郁 

分 类 号：R246.6[医药卫生—针灸推拿学]