老年人血锌含量与认知功能关系的meta分析  

Meta-analysis of the relationship between blood zinc content and cognitive function in older adults

作　　者：梁玉麟 丁晓彤 韦帅芳 李峥[1] LIANG Yulin;DING Xiaotong;WEI Shuaifang;LI Zheng(School of Nursing,Peking Union Medical College,Beijing100144,China)

机构地区：[1]北京协和医学院护理学院,北京100144

出　　处：《中国医药导报》2024年第26期111-117,共7页China Medical Herald

摘　　要：目的系统评价老年人血锌含量与认知功能的关系。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science核心合集数据库、中国知网、万方数据知识服务平台、维普网和中国生物医学文献数据库建库至2024年6月关于老年人血锌含量与认知功能关系的中英文同行评议文献,根据文献类型,采用纽卡斯尔-渥太华量表与美国卫生保健质量和研究机构推荐的偏倚风险评价标准进行质量评价,使用State17进行meta分析。结果共纳入14篇文献,样本量3203例。血锌含量与认知功能量表评分未见显著性相关(r=0.24,95%CI:-0.01,0.49,P=0.06)。认知功能障碍人群血锌含量与普通老年人比较,差异有统计学意义(SMD=-0.21,95%CI:-0.38,-0.03,P=0.02)。不同人群血清锌含量比较,差异有统计学意义(血清:SMD=-0.36,95%CI:-0.51,-0.20,P=0.00),但血浆、全血锌含量比较,差异无统计学意义(血浆:SMD=-0.14,95%CI:-0.64,0.35,P=0.57;全血:SMD=0.02,95%CI:-0.12,0.16,P=0.79)。轻度认知功能障碍人群与健康老人血锌含量比较,差异无统计学意义(SMD=-0.08,95%CI:-0.22,0.06,P=0.27),而阿尔茨海默病亚组比较,差异有统计学意义(SMD=-0.29,95%CI:-0.56,-0.02,P=0.03)。结论当前证据显示,血清锌可能具有认知功能下降生物标志物的潜力,是值得关注并继续探究的指标。Objective To systematically evaluate the association between blood zinc content and cognitive function in older adults.Methods The Chinese and English peer-reviewed literature on the relationship between blood zinc content and cognitive function in older adults was retrieved from the PubMed,Embase,Cochrane Library,Web of Science Core Collection Database,CNKI,Wanfang Data,VIP,and China Biomedical Literature Database from inception until June 2024.According to the type of literature,quality assessment was performed using the Newcastle-Ottawa scale and the bias risk assessment criteria recommended by the Agency for Healthcare Research and Quality,and meta-analysis was performed using State17.Results A total of 14 literatures were included,with a sample size of 3203 cases.There was no significant correlation between blood zinc content and cognitive function scale score(r=0.24,95%CI:-0.01 to 0.49,P=0.06).There was significant difference in blood zinc content between the cognitive dysfunction people and the general elderly(SMD=-0.21,95%CI:-0.38 to-0.03,P=0.02).There were statistically significant differences in serum zinc content among different populations(serum:SMD=-0.36,95%CI:-0.51 to-0.20,P=0.00),but there were no statistically significant differences in plasma and whole blood zinc content(plasma:SMD=-0.14,95%CI:-0.64 to 0.35,P=0.57;Whole blood:SMD=0.02,95%CI:-0.12 to 0.16,P=0.79).There was no statistically significant difference in blood zinc content between the mild cognitive impairment people and the healthy elderly(SMD=-0.08,95%CI:-0.22 to 0.06,P=0.27),while there was statistically significant difference between the Alzheimer’s disease subgroup(SMD=-0.29,95%CI:-0.56 to-0.02,P=0.03).Conclusion Current evidence suggests that serum zinc may have the potential to be a biomarker of cognitive decline and is an indicator that deserves attention and further investigation.

关 键 词：锌 认知功能 老年人 系统评价 

分 类 号：R592[医药卫生—老年医学]