基于数据挖掘探析余小萍教授膏方治疗慢性咳嗽用药规律  

Analysis on the medication rules of Professor Yu Xiaoping for treating chronic cough with cream formula based on data mining

作　　者：王东洋 许悦 朱敏琪[3] 石炜弘 余小萍[1] 沈若冰[1] WANG Dongyang;XU Yue;ZHU Minqi;SHI Weihong;YU Xiaoping;SHEN Ruobing(Department of Traditional Chinese Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai201203,China;International Education College,Shanghai University of Traditional Chinese Medicine,Shanghai201203,China;Department of Ophthalmology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai200025,China;the First Department of Medicine,Shanghai Fangta Hospital of Traditional Chinese Medicine,Shanghai201600,China)

机构地区：[1]上海中医药大学附属曙光医院传统医学科,上海201203 [2]上海中医药大学国际教育学院,上海201203 [3]上海交通大学医学院附属瑞金医院眼科,上海200025 [4]上海市方塔中医医院内一科,上海201600

出　　处：《中国医药导报》2024年第26期168-173,共6页China Medical Herald

基　　金：上海市卫生健康委员会卫生行业临床研究专项面上项目(202340159);上海市名老中医学术经验研究工作室建设项目(SHGZS-202222)。

摘　　要：目的总结余小萍教授膏方治疗慢性咳嗽的用药规律。方法搜集整理2018年11月至2024年2月上海中医药大学附属曙光医院余小萍教授门诊慢性咳嗽膏方,录入中医传承计算平台V 3.5进行证候、中药频次、功效、性味、归经的统计分析、药物关联规则分析和聚类分析。结果共纳入365张膏方,证候虚实夹杂,以肺肾两虚证、肺脾气虚证、痰热阻肺证为主。用药259种,多为补虚药,清热药、化痰止咳平喘药次之,寒温并用,辛开苦降,甘缓补虚,归经以肺、肝、脾胃、肾、心经为主。关联规则分析得到1组由黄芪、熟地黄、麦冬、山茱萸、山药、黄连、吴茱萸、天冬、瓦楞子、丹参、淫羊藿、陈皮、黄芩、半夏、柴胡、郁金构成的核心药物组合和1组21味药的构成的特色药物组合。聚类分析得到4组膏方辅料组合。结论余小萍教授膏方治疗慢性咳嗽虚实并治,熔补虚、清热、化痰、止咳、祛风、化瘀、通络、化湿、理气等法于一炉,注重疏利气机、祛瘀通络、顾护脾胃。Objective To summarize the medication rules of Professor Yu Xiaoping in the treatment of chronic cough with cream formula.Methods The cream formula of Professor Yu Xiaoping’s outpatients with chronic cough in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 2018 to February 2024 were collected and recorded into the Traditional Chinese Medicine Inheritance Computer System V 3.5.Statistical analysis of syndromes,drug frequency,efficacy,nature,and flavour,meridian tropism,drug association rules analysis and cluster analysis were carried out.Results A total of 365 cream formula were included.Syndromes were deficiency and excess complex,and mainly included syndrome of dual deficiency of the lung and kidney,syndrome of lung and spleen qi deficiency and syndrome of phlegm and heat obstructing the lung.A total of 259 kinds of herbs were involved,most of which were tonic herbs,heat-clearing herbs,and resolving phlegm to stop cough and relieve panting herbs.Therapeutic methods were application of both warming and clearing therapies,dispersing with pungent medicinals and descending with bitter medicinals and tonify deficiency with sweet flavor.The main meridian tropisms were lung,liver,spleen,stomach,kidney and heart.A core medicine combination consisting of Astragali Radix,Rehmanniae Radix Praeparata,Ophiopogonis Radix,Corni Fructus,Dioscoreae Rhizoma,Coptidis Rhizoma,Evodiae Fructus,Asparagi Radix,Arcae Concha,Salviae Miltiorrhizae Radix Et Rhizoma,Epimedii Folium,Citri Reticulatae Pericarpium,Scutellariae Radix,Pinelliae Rhizoma,Bupleuri Radix,and Curcumae Radix and a characteristic medicine combination consisting of 21 herbs were obtained by association analysis.Four groups of auxiliary materials were obtained by cluster analysis.Conclusion Professor Yu Xiaoping’s cream formula for the treatment of chronic cough focus on eliminating pathogenic factors and reinforcing healthy qi,integrating multiple therapeutic methods including tonifying,clearing heat,resolving phlegm

关 键 词：数据挖掘 慢性咳嗽 用药规律 中医传承计算平台 膏方 

分 类 号：R256.11[医药卫生—中医内科学]