非酒精性脂肪性肝炎湿热蕴结证“病机证素一体化”PRO量表测评研究  

Evaluation research on PRO scale of“integration of pathogenesis,syndrome and elements”in non-alcoholic steatohepatitis with damp-heat accumulation syndrome

作　　者：陈权 戴正香 孙丽霞 左欣晨 戴恒 史会连 CHEN Quan;DAI Zhengxiang;SUN Lixia;ZUO Xinchen;DAI Heng;SHI Huilian(Department of Hospital Infection Management Office,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210029,China;Department of General Internal Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210029,China;Department of Infection,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210029,China)

机构地区：[1]南京中医药大学附属医院感染管理办公室,江苏南京210029 [2]南京中医药大学附属医院普内科,江苏南京210029 [3]南京中医药大学附属医院感染科,江苏南京210029

出　　处：《中国医药导报》2024年第28期147-150,共4页China Medical Herald

基　　金：国家自然科学基金面上项目(82374360);国家自然科学基金青年科学基金项目(81903974);江苏省自然科学基金面上项目(BK20221421)。

摘　　要：目的探讨非酒精性脂肪性肝炎(NASH)湿热蕴结证“病机证素一体化”患者报告结局(PRO)量表的信度、效度和反应度。方法选取2021年6月至2023年12月于南京中医药大学附属医院就诊的NASH患者630例,发放整理量表问卷数据,采用SPSS 26.0统计学软件对量表信度、效度和反应度进行测评。结果回收有效量表问卷612份。信度:整体Cronbach’sα系数为0.852,湿、热、肝、舌脉4类纬度系数分别为0.851、0.844、0.767、0.798;整体斯皮尔曼-布朗系数为0.732,湿、热、肝、舌脉4类纬度系数分别为0.881、0.872、0.772、0.798。效度:斯皮尔曼系数为0.503~0.796(P<0.05);提取4个成分因子,累积方差百分比达到80.861%;三组量表总分及各纬度得分比较,差异有统计学意义(P<0.05)。反应度:NASH湿热蕴结证患者治疗后4周量表总分及各纬度得分均低于治疗前(P<0.05)。结论本研究PRO量表具有良好的信度、效度及反应度,临床应用价值较高。Objective To investigate the reliability,validity,and reactivity of patient reported outcomes(PRO)scale of“integration of pathogenesis,syndrome and elements”in non-alcoholic steatohepatitis(NASH)with damp-heat accumulation syndrome.Methods A total of 630 NASH patients admitted to Affiliated Hospital of Nanjing University of Chinese Medicine from June 2021 to December 2023 were selected to distribute questionnaire data of the scale,SPSS 26.0 statistical software was used to evaluate the reliability,validity,and responsiveness of the scale.Results A total of 612 effective scale questionnaires were collected.Reliability:the overall Cronbach’sαcoefficient was 0.852,and the four latitude coefficients of dampness,heat,liver and tongue pulse were 0.851,0.844,0.767,and 0.798,respectively.The overall Spearman Brown coefficient was 0.732,and the four latitude coefficients of dampness,heat,liver and tongue pulse were 0.881,0.872,0.772 and 0.798,respectively.Validity:Spearman coefficient was between 0.503-0.796(P<0.05).Four component factors were extracted and the cumulative variance percentage reached 80.861%.There were statistically significant differences in the total scores and each dimension scores of scales among the three groups(P<0.05).Reactivity:after four weeks of treatment,the total score and each dimension scores of scales in NASH patients with damp-heat accumulation syndrome were lower than before treatment(P<0.05).Conclusion In this study,PRO scale has good reliability,validity and reactivity,and has high clinical application value.

关 键 词：非酒精性脂肪性肝炎 患者报告结局 信度 效度 反应度 测评研究 

分 类 号：R256.4[医药卫生—中医内科学]