大黄调节“肠-肾轴”治疗慢性肾脏病的研究进展  

Research progress on the regulation of“gut-kidney axis”by Rhei Radix Et Rhizoma in the treatment of chronic kidney disease

作　　者：周雅萍 贺怡宁 汪兰慧 严茹雪 唐睿婕 何伟明[1] ZHOU Yaping;HE Yining;WANG Lanhui;YAN Ruxue;TANG Ruijie;HE Weiming(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210000,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210000

出　　处：《中国医药导报》2024年第29期53-56,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(82174294);江苏省中医院高水平医院建设重点病种临床研究项目(GSPYY2023004)。

摘　　要：近年来,慢性肾脏病(CKD)已成为全球公共卫生危机,其发病过程隐匿,患者知晓率低且经济代价较高。目前,CKD的致病机制主要归因于肾小球和肾小管间质损伤,从而引发肾纤维化和功能退化,该过程与微炎症和氧化应激密切相关。微炎症状态在CKD的进展过程中扮演重要角色,且其与肠道紊乱有关,“肠-肾轴”理论提出为治疗CKD带来新的研究方向。现代医学针对CKD以积极治疗原发病,严格控制加重肾功能损害的因素为主,而中医药治疗CKD有明显优势。大黄功善通腑泄浊,以“通”为用,使浊邪从肠道而解,在临床上应用丰富,药理学研究证实其可通过改善肠道菌群、修复肠黏膜屏障及调节肠道菌群代谢物在血液中循环等达到延缓CKD进展的目的。本文综述大黄调节“肠-肾轴”治疗CKD的最新研究进展,为临床研究和应用提供一定参考。In recent years,chronic kidney disease(CKD)has become global public health crisis,with a hidden onset process,low patient awareness,and high economic costs.At present,pathogenic mechanism of CKD is mainly attributed to glomerular and tubulointerstitial injury,which leads to renal fibrosis and functional degradation.This process is closely related to microinflammation and oxidative stress.The microinflammatory state plays an important role in the progression of CKD and is related to intestinal disorders,the proposal of“gut-kidney axis”theory brings new research directions in the treatment of CKD.Modern medicine focuses on actively treating the primary disease of CKD and strictly controlling factors that worsen renal function damage,while traditional Chinese medicine has significant advantages in the treatment of CKD.Rhei Radix Et Rhizoma is good at promoting the circulation of organs and eliminating turbidity,it is used for the purpose of“promoting”circulation,allowing turbid pathogens to be released from the intestines,it is widely used in clinical practice.Pharmacological studies have confirmed that it can delay the progression of CKD by improving gut microbiota,repairing intestinal mucosal barrier,and regulating the circulation of gut microbiota metabolites in the bloodstream.This article reviews the latest research progress on the regulation of“gut-kidney axis”by Rhei Radix Et Rhizoma in the treatment of CKD,providing some reference for clinical research and application.

关 键 词：大黄 “肠-肾轴” 慢性肾脏病 

分 类 号：R277.5[医药卫生—中医学]