代谢组学在慢性鼻-鼻窦炎伴鼻息肉中的应用研究进展  

Research progress on the application of metabolomics in chronic rhinosinusitis with nasal polyps

作　　者：郎竟余 郭晴晴 周凌[2] LANG Jingyu;GUO Qingqing;ZHOU Ling(First Clinical Medical College,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Department of Otolaryngology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)

机构地区：[1]黑龙江中医药大学第一临床医学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院耳鼻喉科,黑龙江哈尔滨150040

出　　处：《中国医药导报》2024年第29期68-71,共4页China Medical Herald

基　　金：国家自然科学基金面上项目(81874495);国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)。

摘　　要：慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)的发病机制复杂,以单一学说难以阐释。代谢组学通过定性和定量分析生物系统中的代谢物,为监测疾病状态和阐明发病机制提供新的视角,近年来已被广泛应用于临床研究。为深入了解现阶段代谢组学在CRSwNP中的应用,本文分别对CRSwNP及代谢组学技术进行介绍,并梳理代谢组学在CRSwNP的早期诊断、治疗和预后中的最新研究进展,总结潜在的生物标志物和代谢途径,指出当前研究中存在的挑战,并对代谢组学在该领域的应用前景进行展望。The pathogenesis of chronic rhinosinusitis with nasal polyps(CRSwNP)is complex and difficult to explain with a single theory.Metabolomics provides a new perspective for monitoring disease status and elucidating pathogenesis through qualitative and quantitative analysis of metabolites in biological systems,and has been widely used in clinical research in recent years.In order to further understand the current application of metabolomics in CRSwNP,this paper introduces CRSwNP and metabolomics technology,reviewes the latest research progress of metabolomics in the early diagnosis,treatment,and prognosis of CRSwNP,summarizes potential biomarkers and metabolic pathways,and points out the existing challenges in current research.The application prospect of metabolomics in this field is also prospected.

关 键 词：慢性鼻-鼻窦炎伴鼻息肉 代谢组学 生物标志物 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]