新疆伊犁地区难治性反流性食管炎影响因素分析  

Influencing factors analysis of refractory reflux esophagitis in Yili Area,Xinjiang Uygur Autonomous Region

作　　者：刘姗姗[1] 党旭良 秦健[1] 郭等选 王俊 LIU Shanshan;DANG Xuliang;QIN Jian;GUO Dengxuan;WANG Jun(Department of Gastroenterology,the Fourth Division Hospital of Xinjiang Production and Construction Corps,Xinjiang Uygur Autonomous Region,Yining835000,China;Department of Neurology,the Fourth Division Hospital of Xinjiang Production and Construction Corps,Xinjiang Uygur Autonomous Region,Yining835000,China;Department of General Surgery,Xinhua Hospital of Xinjiang Yili Autonomous Prefecture,Xinjiang Uygur Autonomous Region,Yining835000,China;Department of Gastroenterology,Friendship Hospital of Xinjiang Yili Autonomous Prefecture,Xinjiang Uygur Autonomous Region,Yining835000,China)

机构地区：[1]新疆生产建设兵团第四师医院消化内科,新疆伊宁835000 [2]新疆生产建设兵团第四师医院神经内科,新疆伊宁835000 [3]新疆伊犁哈萨克自治州新华医院普通外科,新疆伊宁835000 [4]新疆伊犁哈萨克自治州友谊医院消化内科,新疆伊宁835000

出　　处：《中国医药导报》2024年第29期111-113,129,共4页China Medical Herald

基　　金：新疆生产建设兵团第四师可克达拉市科技计划项目(2024ZH003)。

摘　　要：目的分析新疆伊犁地区反流性食管炎(RE)病因特点,探讨难治性反流性食管炎(RRE)主要危险因素,为RRE诊治提供依据。方法回顾性收集2023年1月至12月新疆伊犁地区第四师医院、新疆伊犁哈萨克自治州友谊医院、新疆伊犁哈萨克自治州新华医院门诊及住院收治的RE患者713例,根据8周标准质子泵抑制剂治疗是否有效将患者分为普通组和难治组。比较两组一般资料,采用logistic回归分析RRE的影响因素。结果713例RE患者中RRE患者221例(31%)。两组性别,年龄,体重指数(BMI),吸烟,焦虑、抑郁状态,工作性质比较,差异有统计学意义(P<0.05)。多因素logistic回归分析显示:女性(OR=0.656,95%CI:0.455~0.945,P=0.024)是RRE的独立保护因素;年龄(OR=1.675,95%CI:1.255~2.236,P<0.001),BMI(OR=2.432,95%CI:1.875~3.131,P<0.001),焦虑、抑郁状态(OR=5.396,95%CI:3.115~9.347,P<0.001),脑力劳动(OR=12.663,95%CI:7.138~22.466,P<0.001)是RRE的独立危险因素。结论年龄,BMI,焦虑、抑郁状态,脑力劳动是RRE的主要危险因素,临床工作需要积极预防,同时加强医患沟通、确保患者依从性,帮助患者提高疗效及生活质量。Objective To analyze the etiological characteristics of reflux esophagitis(RE)in Yili Area,Xinjiang Uygur Auton-omous Region,and to explore the main influencing factors of refractory reflux esophagitis(RRE),so as to provide evidence for the diagnosis and treatment of RRE.Methods A total of 713 patients of RE patients admitted to the Fourth Division Hospital of Xinjiang Production and Construction Corps,Xinjiang Uygur Autonomous Region,Friendship Hospital of Xinjiang Yili Kazak Autonomous Prefecture,Xinhua Hospital of Xinjiang Yili Kazak Autonomous Prefecture from January to December 2023 were retrospectively collected,patients were divided into normal group or refractory group based on the effectiveness of eight weeks of standard proton pump inhibitor therapy,the general data of the two groups were compared,and the influencing factors affecting RRE were identified by logistic regression analysis.Results Among 713 patients with RE,221 patients(31%)had RRE.Gender,age,body mass index(BMI),smoking,anxiety,depression status and work nature were compared between the two groups,the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that females(OR=0.656,95%CI:0.4555-0.945,P=0.024)were independent protective factors for RRE;age(OR=1.675,95%CI:1.255-2.236,P<0.001),BMI(OR=2.432,95%CI:1.875-3.131),anxiety and depression state(OR=5.396,95%CI:3.115-9.347,P<0.001),and mental work(OR=12.663,95%CI:7.138-22.466,P<0.001)were independent protective factors for RRE.Conclusion Age,BMI,anxiety and depression,and mental work are the main risk factors of RRE.Clinical work needs to be actively prevented,and at the same time,communication between doctors and patients should be strengthened to ensure patient compliance and help patients improve their curative effect and quality of life.

关 键 词：难治性反流性食管炎 病因 临床病例分析 危险因素 

分 类 号：R587.1[医药卫生—内分泌]