当归芍药散治疗妇科疾病的临床及基础研究进展  

Clinical and basic research progress of Danggui Shaoyao Powder in the treatment of gynecological diseases

作　　者：王玲 马雪琦 张春兰[2] 孟小钰[2] 郝松莉[2] WANG Ling;MA Xueqi;ZHANG Chunlan;MENG Xiaoyu;HAO Songli(Graduate School of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Department of Gynecology,First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科,黑龙江哈尔滨150040

出　　处：《中国医药导报》2024年第30期50-54,共5页China Medical Herald

基　　金：黑龙江省中医药科研项目(ZYW2024-045)。

摘　　要：当归芍药散是中国东汉时期著名医学家张仲景的经典名方,主治妇人腹痛。随着现代医学研究的深入,发现当归芍药散在临床的应用范围远不止于此,对盆腔炎性疾病、痛经、多囊卵巢综合征和子宫内膜异位症等多种妇科疾病均有显著效果。本文对当归芍药散从调控PI3K/Akt、核因子κB、转化生长因子-β1等信号通路表达及调节下丘脑-垂体-卵巢轴功能、调节免疫、控制炎症、改善血液流变学、保护血管内皮等方面治疗妇科疾病进行总结,为妇科疾病的有效治疗提供新的思路和方法,进一步推动当归芍药散在临床中应用和现代研究的深入发展。Danggui Shaoyao Powder is a classic prescription of Zhang Zhongjing,a famous medical scientist in the Eastern Han Dynasty of China,treating women with abdominal pain.With the deepening of modern medical research,it is found that Danggui Shaoyao Powder is far more than this in clinical application,for pelvic inflammatory disease,dysmenorrhea,polycystic ovary syndrome,endometriosis and other gynecological diseases have significant curative effect.This article summarizes the treatment of gynecological diseases by Danggui Shaoyao Powder from regulating the expression of PI3K/Akt,NF-κB,TGF-β1 signaling pathway,regulating hypothalamic-pituitary-ovarian axis function,regulating immunity,controlling inflammation,improving hemorheology,and protecting vascular endothelium,etc.It provides new ideas and methods for the effective treatment of gynecological diseases,and further promotes clinical application of Danggui Shaoyao Powder and the in-depth development of modern research.

关 键 词：当归芍药散 妇科疾病 研究进展 

分 类 号：R271.9[医药卫生—中西医结合]