氟18-成纤维细胞激活蛋白抑制剂-04与氟18-氟脱氧葡萄糖在胃中低分化腺癌患者显像中的对比研究  

Comparative study of fluorine 18-fibroblast activation protein inhibitor-04 and fluorine 18-fluorodeoxyglucose in imaging of patients with moderately and poorly differentiated gastric adenocarcinoma

作　　者：张莹[1] 柳江燕[1] 田小雪 崔振存 张凯 沈亦敏 付静瑜 彭岱云 ZHANG Ying;LIU Jiangyan;TIAN Xiaoxue;CUI Zhencun;ZHANG Kai;SHEN Yimin;FU Jingyu;PENG Daiyun(Department of Nuclear Medicine,the Second Hospital,Lanzhou University,Gansu Province,Lanzhou730000,China)

机构地区：[1]兰州大学第二医院核医学科,甘肃兰州730000

出　　处：《中国医药导报》2024年第31期154-159,共6页China Medical Herald

基　　金：甘肃省自然科学基金项目(22JR5RA989);甘肃省联合科研基金一般项目(24JRRA922);甘肃省兰州大学萃英科技创新计划面上项目(CY2023-MS-B10);甘肃省兰州大学萃英科技创新计划青年基金项目(CY2021-QN-B12)。

摘　　要：目的比较氟18-成纤维细胞激活蛋白抑制剂-04(^(18)F-FAPI-04)与氟18-氟脱氧葡萄糖(^(18)F-FDG)正电子发射断层扫描(PET)显像在胃中低分化腺癌患者的生物分布和诊断价值。方法选取2022年9月至2023年12月就诊于兰州大学第二医院核医学科的10例胃中低分化腺癌患者为研究对象。患者10 d内采用^(18)F-FDG和^(18)F-FAPI-04 PET/CT扫描,比较肿瘤组织和正常组织摄取两种显像剂的最大标准化摄取值(SUV_(max))和肿瘤与背景比(TBR),评估其生物分布和诊断价值。结果^(18)F-FAPI-04 PET/CT显像对恶性病灶的检出率较^(18)F-FDG PET/CT增加41%。给药60 min后,脑、甲状腺、心肌、血池、骨骼肌、肝、胰腺、脾、肾、结肠、前列腺、转移病灶和所有恶性病灶摄取^(18)F-FAPI-04和^(18)F-FDG的SUV_(max)比较,差异有统计学意义(P<0.05)。转移性淋巴结和肝转移灶摄取^(18)F-FAPI-04和^(18)F-FDG的SUV_(max)比较,差异有统计学意义(P<0.05)。^(18)F-FAPI-04与^(18)F-FDG显像肿瘤原发灶以瘤周正常组织、纵隔血池为背景的TBR比较,差异有统计学意义(P<0.05)。^(18)F-FAPI-04与^(18)F-FDG显像以纵隔血池为背景的转移性淋巴结、以肝实质为背景的肝转移灶、以脂肪组织为背景的腹膜转移灶、以骨组织为背景的骨转移灶、以肺实质为背景的肺转移灶的TBR比较,差异有统计学意义(P<0.05)。结论^(18)F-FAPI-04对胃中低分化腺癌显示出比^(18)F-FDG更优越的诊断性能。Objective To compare the biodistribution and diagnostic value of fluorine 18-fibroblast activation protein inhibitor-04(^(18)F-FAPI-04)and fluorine 18-fluorodeoxyglucose(^(18)F-FDG)positron emission tomography(PET)imaging in patients with moderately and poorly differentiated gastric adenocarcinoma.Methods A total of ten patients with moderately and poorly differentiated gastric adenocarcinoma visited Department of Nuclear Medicine,the Second Hospital in Lanzhou University from September 2022 to December 2023 were selected as the research subjects.^(18)F-FDG and^(18)F-FAPI-04 PET/CT scans were performed on patients within ten days.The_(max)imum standardized uptake value(SUV_(max))and tumor to background ratio(TBR)of two imaging agents between tumor tissue and normal tissue were compared.Biological distribution and diagnostic value were evaluated.Results The detection rate of malignant lesions by^(18)F-FAPI-04 PET/CT imaging was 41%,higher than that of^(18)F-FDG PET/CT imaging.After administration of 60 minutes,there were statistically significant differences in SUV_(max)uptake of^(18)F-FAPI-04 and^(18)F-FDG among brain,thyroid,myocardium,blood pool,skeletal muscle,liver,pancreas,spleen,kidney,colon,prostate,metastatic lesions,and all malignant lesions(P<0.05).There were statistically significant differences in SUV_(max)between^(18)F-FAPI-04 and^(18)F-FDG uptake in metastatic lymph nodes and liver metastases(P<0.05).There were statistically significant differences in TBR between^(18)F-FAPI-04 and^(18)F-FDG imaging of tumor primary lesions with normal tissue around the tumor and mediastinal blood pool as background(P<0.05).There were statistically significant differences in TBR between^(18)F-FAPI-04 and^(18)F-FDG imaging for metastatic lymph nodes with mediastinal blood pool background,liver metastases with liver parenchyma background,peritoneal metastases with adipose tissue background,bone metastases with bone tissue background,and lung metastases with lung parenchyma background(P<0.05).Conclusion^(18)F-FAPI-04 sh

关 键 词：氟18-成纤维细胞激活蛋白抑制剂-04 氟18-氟脱氧葡萄糖 正电子发射断层扫描 胃中低分化腺癌 

分 类 号：R445[医药卫生—影像医学与核医学]