子痫前期孕妇外周血单核细胞整合素αM的表达及临床意义  

Expression and clinical significance of integrin αM in peripheral blood mononuclear cells of pregnant women with preeclampsia

作　　者：郭瑜 周永红 魏丹 张冰 何荣霞[2] GUO Yu;ZHOU Yonghong;WEI Dan;ZHANG Bing;HE Rongxia(The Second Clinical Medical School,Lanzhou University,Gansu Province,Lanzhou730030,China;Department of Obstetrics,the Second Hospital&Clinical Medical School,Lanzhou University,Gansu Province,Lanzhou730030,China)

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730030 [2]兰州大学第二医院产科,甘肃兰州730030

出　　处：《中国医药导报》2024年第27期118-123,共6页China Medical Herald

摘　　要：目的探讨子痫前期孕妇外周血单核细胞表面整合素αM(ITGAM)的表达水平及其潜在的临床意义。方法选取兰州大学第二医院2023年3月至2024年3月收治的40例子痫前期孕妇作为病例组,并根据病情严重程度分为子痫前期组(M-PE,19例)和重度子痫前期组(S-PE,21例)两组。另选取同期就诊于兰州大学第二医院的年龄、孕龄匹配的40名健康孕妇作为对照组。采用流式细胞术检测两组孕妇外周血单核细胞表面ITGAM的表达情况,并分析其与各组孕妇临床特征之间的相关关系。结果病例组外周血单核细胞表面ITGAM表达水平低于对照组(P<0.05),进一步分析显示,S-PE组ITGAM表达水平低于对照组(P<0.05),对照组与M-PE组、S-PE组与M-PE组ITGAM表达水平比较,差异无统计学意义(P>0.05)。病例组单核细胞表面ITGAM的表达水平与24 h尿蛋白定量、LDH呈负相关(r=-0.344、-0.384,P=0.030、0.014),与ALB呈正相关(r=0.389,P=0.013);对照组孕妇ITGAM表达与血小板呈负相关(r=-0.383,P=0.015)。结论子痫前期孕妇外周血单核细胞表面ITGAM表达水平的降低可能参与了其发病过程,并可能与其肾损伤程度及病情严重程度存在一定的联系。Objective To investigate the expression level of integrin αM(ITGAM)on peripheral mononuclear cells of pregnant women with preeclampsia and its potential clinical significance.Methods A total of 40 pregnant women with preeclampsia who were treated in the Second Hospital&Clinical Medical School,Lanzhou University from March 2023 to March 2024 were selected as the case group,and they were divided into two groups according to the severity of the disease:mild preeclampsia group(M-PE,19 cases)and severe preeclampsia group(S-PE,21 cases).Another 40 healthy pregnant women with matching age and gestational age who were admitted to the Second Hospital&Clinical Medical School Lanzhou University during the same period were selected as the control group.Flow cytometry was used to detect ITGAM expression on peripheral blood mononuclear cells of pregnant women in two groups,and the correlation between ITGAM expression and clinical features of pregnant women in each group was analyzed.Results The expression level of ITGAM on peripheral blood mononuclear cells of the case group was lower than that of the control group(P<0.05),and further analysis showed that the expression level of ITGAM in the S-PE group was lower than that in the control group(P<0.05),there was no statistical significance between control and M-PE group,and between S-PE and M-PE group.The expression level of ITGAM on the surface of monocytes in the case group was negatively correlated with 24 h urinary protein quantity and LDH(r=-0.344,-0.384,P=0.030,0.014),and positively correlated with ALB(r=0.389,P=0.013).The expression of ITGAM in the control group was negatively correlated with platelet(r=-0.383,P=0.015).Conclusion The decreased expression level of ITGAM on peripheral blood mononuclear cells of preeclampsia pregnant women may be involved in its pathogenesis,and may be related to the degree of kidney injury and the severity of the disease.

关 键 词：子痫前期 外周血 单核细胞 整合素αM 

分 类 号：R714.24[医药卫生—妇产科学]