1例过量服用左旋多巴诱发严重异动症帕金森病患者的药学监护文献回顾分析  

Review of the literature on pharmaceutical care of 1 case of Parkinson's disease with severe dyskinesia induced by overdose of levodopa

作　　者：李嘉鑫 王艺霏 LI Jia-xin;WANG Yi-fei(Pharmaceutical Department,Dalian Joint Logistic Support Force Rehabilitation and Convalescence Center,Dalian 116013,China)

机构地区：[1]联勤保障部队大连康复疗养中心药剂科,116013

出　　处：《中国现代药物应用》2024年第22期140-144,共5页Chinese Journal of Modern Drug Application

摘　　要：分析1例因过量服用左旋多巴(L-DOPA)诱发严重异动症帕金森病(PD)患者的药物治疗及药学监护情况,探讨临床药师参与预防和治疗L-DOPA相关并发症的重要意义。临床药师通过分析病例及相关文献,在该晚期PD患者的治疗过程中积极开展药学监护和用药教育,协助临床医生优化治疗方案。医生采纳临床药师提出的建议后,患者近端肌力由Ⅱ级恢复至Ⅴ级、肌张力由Ⅳ级恢复正常,运动并发症状明显改善,恢复运动能力后康复出院。临床药师发挥专业特长,协助医师为患者提供安全有效的治疗方案,并通过用药教育提高了患者的用药依从性,体现了临床药师开展PD患者药学监护的重要意义。This paper analyzes the drug treatment and pharmaceutical care of 1 patient with Parkinson's disease(PD) induced by overdose of levodopa(L-DOPA),and explores the significance of clinical pharmacists' participation in the prevention and treatment of L-DOPA-related complications.Clinical pharmacists actively carried out pharmaceutical care and medication education during the treatment of patients with advanced PD by analyzing cases and related literature,assisting clinicians to optimize the treatment plan.After adopting the suggestions put forward by the clinical pharmacist,the patient's proximal muscle strength recovered from grade Ⅱ to grade Ⅴ,and muscle tension returned to normal from grade Ⅳ.The symptoms of exercise complications has been improved significantly,and the patient has recovered and discharged after regaining exercise ability.Clinical pharmacists give full play to their professional expertise,assist physicians to provide patients with safe and effective treatment plans,and improve patients' medication compliance through medication education,which reflects the significance of clinical pharmacists to carry out pharmaceutical care for PD patients.

关 键 词：帕金森病 异动症 左旋多巴 药学监护 

分 类 号：R969.3[医药卫生—药理学]