NT-proBNP、D-D、NLR联合检测对急性肺栓塞的临床诊断价值  

Clinical value of NT-proBNP,D-dimer and NLR combined detection in the diagnosis of acute pulmonary embolism

作　　者：胡斯明 李勇[1] 金明华[1] HU Si-ming;LI Yong;JIN Ming-hua(Department of Respiratory and Critical Care Medicine,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215000,China)

机构地区：[1]南京医科大学附属苏州医院呼吸与危重症医学科,215000

出　　处：《中国实用医药》2024年第22期81-83,共3页China Practical Medicine

摘　　要：目的 研究N末端脑利钠肽前体(NT-proBNP)、D-二聚体(D-D)、中性粒细胞与淋巴细胞比值(NLR)联合检测对急性肺栓塞的临床诊断价值。方法 选取60例急性肺栓塞患者作为肺栓塞组,其中30例为中危肺栓塞、30例为低危肺栓塞,另选择60例健康体检者作为对照组。入院后24 h内,采集所有受试者静脉血5 ml检测NT-proBNP、D-D、NLR水平。比较肺栓塞组与对照组、肺栓塞组中中危肺栓塞患者与低危肺栓塞患者的NT-proBNP、D-D、NLR水平,并分析NT-proBNP、D-D、NLR联合检测对急性肺栓塞的诊断灵敏度和特异度。结果 肺栓塞组NT-proBNP(412.68±181.29)pg/ml、D-D(8.78±1.75)mg/L、NLR(5.60±0.35)均高于对照组的(84.30±9.21)pg/ml、(0.24±0.02)mg/L、(1.33±0.21),有显著差异(P<0.05)。中危肺栓塞患者NT-proBNP(613.22±231.49)pg/ml、D-D(9.65±0.64)mg/L、NLR(6.86±0.96)均高于低危肺栓塞患者的(212.13±119.46)pg/ml、(7.91±0.91)mg/L、(4.33±0.31),有显著差异(P<0.05)。NT-proBNP、D-D、NLR联合检测急性肺栓塞灵敏度93.3%高于NT-proBNP检测的68.3%、NLR检测的73.3%,有显著差异(P<0.05);特异度61.7%与D-D检测的61.7%、NT-proBNP检测的66.7%、NLR检测的65.0%比较,无显著差异(P>0.05)。结论 利用NT-proBNP、D-D、NLR联合检测对急性肺栓塞患者进行诊断,能够在早期判断其危险程度,具有重要的临床指导意义。Objective To study the clinical value of N-terminal pro-brain natriuretic peptide(NT-proBNP),D-dimer(D-D) and neutrophils to lymphocyte ratio(NLR) combined detection in the diagnosis of acute pulmonary embolism.Methods A total of 60 patients with acute pulmonary embolism were selected as the pulmonary embolism group,including 30 patients with medium-risk pulmonary embolism and 30 patients with low-risk pulmonary embolism,and 60 healthy subjects were selected as the control group.Within 24 h after admission,5 ml of venous blood was collected from all subjects to detect the levels of NT-proBNP,D-D and NLR.The levels of NT-proBNP,D-D,and NLR were compared between the pulmonary embolism group and the control group,and between patients with medium-risk pulmonary embolism and patients with low-risk pulmonary embolism in the pulmonary embolism group,and the diagnostic sensitivity and specificity of the combined detection of NT-proBNP,D-D,and NLR for acute pulmonary embolism were analyzed.Results The pulmonary embolism group had NT-proBNP of(412.68±181.29) pg/ml,D-D of(8.78±1.75) mg/L and NLR of(5.60±0.35),which were significantly higher than(84.30±9.21) pg/ml,(0.24±0.02) mg/L and(1.33±0.21)in the control group,and there was significant difference(P<0.05).In patients with medium-risk pulmonary embolism,NT-proBNP was(613.22±231.49) pg/ml,D-D was(9.65±0.64) mg/L,and NLR was(6.86±0.96),which were significantly higher than(212.13±119.46) pg/ml,(7.91±0.91) mg/L,and(4.33±0.31) in patients with low-risk pulmonary embolism,and there was significant difference(P<0.05).The sensitivity of the combined detection of NT-proBNP,D-D,and NLR for acute pulmonary embolism was 93.3%,which was higher than 68.3%of NT-proBNP and 73.3% of NLR,and there was significant difference(P<0.05);the specificity of the combined detection was 61.7%,which had no significant difference compared with 61.7% of D-D,66.7% of NT-proBNP and 65.0% of NLR(P>0.05).Conclusion Combined detection of NT-proBNP,D-D and NLR for patients with acute pulmonary em

关 键 词：N末端脑利钠肽前体 D-二聚体 中性粒细胞与淋巴细胞比值 急性肺栓塞 诊断价值 

分 类 号：R563.5[医药卫生—呼吸系统]