参芪地黄汤配合沙库巴曲缬沙坦钠片治疗糖尿病肾病临床研究  

Clinical Study on the Treatment of Diabetic Nephropathy with Ginseng and Astragalus and Rehmannia Decoction Combined with Sacubitril Valsartan Sodium Tablets

作　　者：康豪鹏 徐晓妍[2] KANG Haopeng;XU Xiaoyan(Henan Electric Power Hospital,Zhengzhou,Henan,China,450052;The First Affiliated Hospital of Henan University of CM,Zhengzhou,Henan,China,450001)

机构地区：[1]河南电力医院,河南郑州450052 [2]河南中医药大学第一附属医院,河南郑州450001

出　　处：《河南中医》2024年第12期1909-1913,共5页Henan Traditional Chinese Medicine

基　　金：2022年全国名老中医药专家传承工作室建设项目{国中医药人教函〔2022〕76号}。

摘　　要：目的:观察参芪地黄汤配合沙库巴曲缬沙坦钠片治疗糖尿病肾病(diabetic nephropathy,DN)的临床疗效。方法:选取2022年1月至2023年6月河南电力医院收治的DN患者102例,按照随机数字表法分为对照组和观察组,每组51例。对照组给予常规治疗,观察组在对照组治疗的基础上给予参芪地黄汤治疗。观察两组患者治疗前后中医证候总积分、空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2 h postprandial blood glucose,2 h PBG)、血清胱抑素(cystain C,Cys-c)、视黄醇结合蛋白(retinol binding protein,RBP)水平及临床疗效、不良反应发生情况。结果:观察组有效率为86.27%,对照组有效率为68.63%,观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后中医证候总积分低于对照组,差异有统计学意义(P<0.05);观察组治疗后FBG、2 h PBG水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后Cys-c、RBP水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:参芪地黄汤联合沙库巴曲缬沙坦钠片治疗糖尿病肾病,可提高临床疗效,缓解中医证候,有效调节血糖水平,改善肾功能。Objective:To observe the clinical efficacy of Ginseng and Astragalus and Rehmannia Decoction combined with Sacubitril Valsartan Sodium Tablets on diabetic nephropathy(DN).Methods:A total of 102 DN patients admitted to Henan Electric Power Hospital between January 2022 and June 2023 were selected and randomly divided into the control group and the observation group,with 51 cases in each group.The control group received conventional treatment,while the observation group was additionally treated with Ginseng and Astragalus and Rehmannia Decoction.The changes in total TCM symptom scores,fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h PBG),serum cystatin C(Cys-C),and retinol binding protein(RBP)levels,as well as clinical efficacy and adverse reactions before and after treatment were observed.Results:The effective rate of the observation group was 86.27%,significantly higher than 68.63%in the control group,with a statistical difference(P<0.05).After treatment,the total TCM symptom scores in the observation group were lower than those of the control group,with a significant difference(P<0.05);FBG and 2 h PBG levels in the observation group were significantly lower than those in the control group,with statistical differences(P<0.05);Serum Cys-C and RBP levels in the observation group were lower than those in the control group,with statistical significances(P<0.05).However,no significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Ginseng and Astragalus and Rehmannia Decoction and Sacubitril Valsartan Sodium Tablets can improve the clinical efficacy in the treatment of DN,alleviate TCM symptoms,effectively regulate blood glucose levels,and improve renal function.

关 键 词：糖尿病肾病 参芪地黄汤 沙库巴曲缬沙坦钠片 血糖 肾功能 中西医结合疗法 

分 类 号：R259.872[医药卫生—中西医结合]