金属多酚基纳米材料的抗菌性能  

Antibacterial properties of metal polyphenol-based nanomaterials

作　　者：侯俊[1] 范玥 杨梓俊 吴军 尤国祥 苗令占 HOU Jun;FAN Yue;YANG Zi-jun;WU Jun;YOU Guo-xiang;MIAO Ling-zhan(College of Environment,Hohai University,Key Laboratory of Integrated Regulation and Resources Development on Shallow Lakes of Ministry of Education,Nanjing 210098,China)

机构地区：[1]河海大学环境学院,浅水湖泊综合整治与资源开发教育部重点实验室,江苏南京210098

出　　处：《中国环境科学》2024年第12期7011-7023,共13页China Environmental Science

基　　金：国家自然科学基金区域联合重点项目(U23A2058);中央高校优秀青年团队培育项目(B230201058);江苏省重点研发计划项目(BE2022834)。

摘　　要：以单宁酸和多种不同的金属为原料,通过一步共混法制备金属多酚基纳米抗菌材料(MPNs),并将其应用于对革兰氏阴性菌(大肠杆菌)以及革兰氏阳性菌(金黄色葡萄球菌)的抗菌研究.结果表明,MPNs在光下能够协同光热抗菌和光动力抗菌,从而在不引发细菌耐药性的同时高效抗菌,MPNs体系中金属的掺杂在一定程度上有助于MPNs在光下的抗菌性能.以抗菌效果为指标筛选出一种具有最优抗菌效果(大于98%)的金属多酚基半导体纳米抗菌材料(TA@Fe-TiO2MPN),并通过紫外可见固体漫反射以及XPS分析探究其抗菌机制.结果表明,由于TA@Fe金属多酚网络在TiO2上引入的氧空位,TA@Fe-TiO2MPN具有宽广的光响应范围以及增强的电子活性,使得TA@Fe-TiO2MPN在全波段光照下具有增强且持续的活性氧产生能力(羟基自由基·OH和单线氧1O2)以及接近100%的抗菌性能.Using tannic acid and a variety of different metals as raw materials,metal-polyphenol based nano-antibacterial materials(MPNs)were prepared by one-step blending method,and applied to the antibacterial of gram-negative bacteria(E.coli)and gram-positive bacteria(S.aureus).The results showed that MPNs could cooperate photothermal antibacterial strategy with photodynamic antibacterial strategy under light to effectively resist bacteria without triggering bacterial resistance.The metal doping in the MPNs system was helpful to the antibacterial performance of MPNs under light to a certain extent.Taking the antibacterial effect as an indicator,a metal-polyphenol based semiconductor nano-antibacterial material(TA@Fe-TiO_(2) MPN)with the best antibacterial effect(more than 98%)was screened out,and its antibacterial mechanism was explored through DRS and XPS analysis.The results indicated that due to the oxygen vacancy introduced by TA@Fe on TiO_(2),TA@Fe-TiO_(2) MPN had a wide range of light response and enhanced electronic activity which enabled TA@Fe-TiO_(2) MPN to have enhanced and sustained reactive oxygen production(hydroxyl radical·OH and singlet oxygen 1O_(2))and nearly 100%antibacterial properties under full-band illumination.

关 键 词：金属多酚 光热抗菌策略 光动力抗菌策略 无抗生素纳米抗菌材料 氧空位 

分 类 号：X52[环境科学与工程—环境工程] X17