慢性硬膜下血肿患者微创钻孔引流术后联合阿托伐他汀的应用效果研究  

Effect of Minimally Invasive Drilling and Drainage Combined with Atorvastatin in Patients with Chronic Subdural Hematoma

作　　者：冯静 王亚军 宋巽锋 FENG Jing;WANG Yajun;SONG Xunfeng(Department of Neurosurgery,Meitan County People's Hospital,Zunyi,Guizhou,564100,China)

机构地区：[1]贵州省湄潭县人民医院神经外科,贵州遵义564100

出　　处：《中外医疗》2024年第31期5-8,共4页China & Foreign Medical Treatment

摘　　要：目的探究慢性硬膜下血肿患者微创钻孔引流术后采用阿托伐他汀治疗的效果。方法方便选取2018年5月—2023年5月贵州省湄潭县人民医院接诊的48例慢性硬膜下血肿患者为研究对象,依据不同治疗方法分成对照组与联合组,各24例。对照组接受微创钻孔引流术和地塞米松治疗,联合组在对照组的基础上口服阿托伐他汀治疗。对比两组患者残余血肿量、神经功能和日常生活能力评分、并发症发生率及复发率。结果治疗后7 d、15 d、1个月及3个月,两组患者残余血肿量明显低于治疗前,且联合组各时间点残留血肿量少于对照组,差异有统计学意义(P均<0.05)。治疗后,联合组神经功能指标及评分均优于对照组,日常生活能力评分高于对照组,差异有统计学意义(P均<0.05)。联合组患者术后并发症总发生率为4.17%(1/24),明显低于对照组的33.33%(8/24),差异有统计学意义(χ2=4.923,P=0.027)。联合组复发率为4.17%(1/24),显著低于对照组的25.00%(6/24),差异有统计学意义(χ2=4.181,P=0.041)。结论针对慢性硬膜下血肿患者,应用微创钻孔引流手术,并在术后结合阿托伐他汀药物疗法,不仅可提升神经功能、日常生活能力,还可有效减少残余血肿量,减少术后并发症,降低复发率。Objective To investigate the effect of atorvastatin therapy on patients with chronic subdural hematoma after minimally invasive trepanation and drainage.Methods Forty-eight patients with chronic subdural hematoma treated in Meitan County People's Hospital of Guizhou Province from May 2018 to May 2023 were conveniently selected as the study objects,and divided into the control group and the combination group according to different treatment methods,with 24 cases in each group.The control group received minimally invasive trephination and drainage and dexamethasone,and the combination group received oral atorvastatin therapy on the basis of the reference group.Residual hematoma volume,nerve function and daily living ability score,complication rate and recurrence rate were compared between the two groups.Results After 7 days,15 days,1 month and 3 months of treatment,the volume of residual hematoma in the two groups was significantly lower than that before treatment,and the residual hematoma volume in the combination group was less than that in the control group at each time point,and the differences were statistically significant(all P<0.05).After treatment,the neurological function indexes and scores of the combination group were better than those of the control group,and the scores of daily living ability were higher than those of the control group,the differences were statistically significant(all P<0.05).The total incidence of postoperative complications in the combination group was 4.17%(1/24),which was significantly lower than that in the control group 33.33%(8/24),the difference was statistically significant(χ2=4.923,P=0.027).The recurrence rate of the combination group was 4.17%(1/24),which was significantly lower than that of the control group 25.00%(6/24),the difference was statistically significant(χ2=4.181,P=0.041).Conclusion For patients with chronic subdural hematoma,the application of minimally invasive trepanation and drainage,combined with atorvastatin therapy after surgery,can not only improve ne

关 键 词：神经功能 慢性硬膜下血肿 微创钻孔引流术 阿托伐他汀 

分 类 号：R4[医药卫生—临床医学]