血液透析联合血液灌流治疗对尿毒症患者肾功能的影响分析  

Analysis of the Effect of Hemodialysis Combined with Hemoperfusion on Renal Function in Patients with Uremia

作　　者：董璐露 陈佳[2] 黄秀玲 曾令军 DONG Lulu;CHEN Jia;HUANG Xiuling;ZENG Lingjun(Third Department of Internal Medicine,Nanxiong People'S Hospital,Nanxiong,Guangdong,512400,China;De-partment of Cardiology,Guangdong Second People's Hospital,Guangzhou,Guangdong,510000,China)

机构地区：[1]南雄市人民医院内三科,广东南雄512400 [2]广东省第二人民医院心内科,广东广州510000

出　　处：《中外医疗》2024年第31期9-13,共5页China & Foreign Medical Treatment

基　　金：韶关市卫生健康科研项目(Y23149)。

摘　　要：目的评价血液透析+血液灌流治疗尿毒症对患者肾功能的影响。方法随机选取2021年1月—2023年12月南雄市人民医院内三科收治的100例尿毒症患者为研究对象,依据不同治疗方法分为对照组(血液透析治疗,50例)与干预组(血液透析+血液灌流治疗,50例),比较两组患者临床疗效、肾功能指标、炎性因子水平、血管内皮功能指标和T淋巴细胞亚群水平。结果干预组总有效率为96.00%(48/50),高于对照组的80.00%(40/50),差异有统计学意义(χ2=6.061,P<0.05)。治疗后,干预组T淋巴细胞亚群水平均高于对照组,肾功能指标、炎性因子、血管内皮功能指标水平均低于对照组,差异有统计学意义(P均<0.05)。结论血液透析+血液灌流应用于尿毒症患者治疗中的效果显著,可改善肾功能指标、炎性因子、血管内皮功能指标和T淋巴细胞亚群水平。Objective To evaluate the effect of hemodialysis+hemoperfusion on renal function in patients with uremia.Methods A total of 100 uremia patients admitted to the Third Departments of Internal Medicine of Nanxiong People's Hospital from January 2021 to December 2023 were randomly selected as the study objects.According to different treatment methods,they were divided into control group(hemodialysis treatment,50 cases)and intervention group(hemodialysis+hemopirrigation treatment,50 cases).The clinical efficacy,renal function,the level of inflammatory factors,vascular endothelial function and T lymphocyte subsets were compared between the two groups.Results The total effective rate in the intervention group was 96.00%(48/50),which was higher than that in the control group 80.00%(40/50),the difference was statistically significant(χ2=6.061,P<0.05).After treatment,the levels of T lymphocyte subsets in the intervention group were higher than those in the control group,and the levels of renal function indexes,inflammatory factors and vascular endothelial function indexes were lower than those in the control group,the differences were statistically significant(all P<0.05).Conclusion Hemodialysis and hemoperfusion can improve renal function,inflammatory factors,vascular endothelial function and T lymphocyte subsets in the treatment of uremia patients.

关 键 词：血液透析 血液灌流 尿毒症 肾功能 

分 类 号：R692.5[医药卫生—泌尿科学]