复元和中汤联合穴位贴敷对胃癌SOX化疗患者的血清T淋巴细胞亚群及肿瘤标志物的影响  

The Effect of Fuyuan Hezhong Tang Combined with Acupoint Application on Serum T Lymphocyte Subsets and Tumor Markers in Gastric Cancer Patients Undergoing SOX Chemotherapy

作　　者：张娜 胡晶 李建翠 ZHANG Na;HU Jing;LI Jiancui(Department of OncologyⅠ,Jinan Integrated Traditional Chinese and Western Medicine Hospital,Jinan,Shandong,271100,China)

机构地区：[1]济南市中西医结合医院肿瘤一科,山东济南271100

出　　处：《中外医疗》2024年第31期182-186,共5页China & Foreign Medical Treatment

摘　　要：目的分析复元和中汤联合穴位贴敷对胃癌SOX化疗患者的血清T淋巴细胞亚群及肿瘤标志物的影响。方法方便选取2021年2月—2023年2月济南市中西医结合医院收治的94例胃癌SOX化疗患者为研究对象,依据不同治疗方法分为两组,各47例。对照组采用复元和中汤治疗,观察组采用复元和中汤联合穴位贴敷治疗,21 d为1个疗程,持续治疗4个疗程。比较两组患者临床疗效、T淋巴细胞亚群、肿瘤标志物水平、不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者CD3^(+)、CD4^(+)、CD8^(+)水平比较,差异无统计学意义(P均>0.05);治疗后,观察组CD3^(+)为(55.61±3.97)%、CD4^(+)为(45.97±3.52)%,高于对照组的(49.70±3.25)%、(38.64±2.83)%,CD8^(+)为(19.84±1.25)%,低于对照组的(23.11±1.67)%,差异有统计学意义(t=7.897、11.126、10.747,P均<0.001)。治疗前,两组患者肿瘤标志物水平比较,差异无统计学意义(P均>0.05);治疗后,观察组癌胚抗原为(6.40±0.94)ng/mL、糖类抗原242为(28.35±1.88)U/mL、糖类抗原199为(41.39±3.27)U/mL、糖类抗原724为(9.21±1.05)U/mL,低于对照组的(8.53±1.25)ng/mL、(35.41±2.19)U/mL、(46.58±4.05)U/mL、(14.38±1.67)U/mL,差异有统计学意义(t=9.337、16.769、6.836、17.968,P均<0.001)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论复元和中汤联合穴位贴敷能够改善胃癌SOX化疗患者的免疫功能,降低肿瘤标志物水平,且无严重不良反应。Objective To analyze the effect of Fuyuan Hezhong Tang decoction combined with acupoint application on serum T lymphocyte subsets and tumor markers in patients with gastric cancer undergoing SOX chemotherapy.Methods A total of 94 gastric cancer patients treated with SOX chemotherapy in Jinan Integrated Traditional Chinese and Western Medicine Hospital from February 2021 to February 2023 were conveniently selected as the research objects.According to different treatment methods,they were divided into two groups,with 47 cases in each group.The control group was treated with Fuyuan Hezhong Tang,the observation group was treated with Fuyuan Hezhong Tang combined acupoint application,21 d as a course of treatment,continuous treatment for 4 courses.The clinical efficacy,T lymphocyte subsets,tumor marker levels and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of CD3^(+),CD4^(+)and CD8^(+)between the two groups(all P>0.05);after treatment,CD3^(+)and CD4^(+)in observation group were(55.61±3.97)%and(45.97±3.52)%,higher than those in control group(49.70±3.25)%and(38.64±2.83)%,and CD8^(+)were(19.84±1.25)%,lower than those in control group(23.11±1.67)%,and the differences were statistically significant(t=7.897,11.126,10.747,all P<0.001).Before treatment,there was no significant difference in the level of tumor markers between the two groups(P>0.05);after treatment,the carcinoembryonic antigen of the observation group was(6.40±0.94)ng/mL,carbohydrate antigen 242 was(28.35±1.88)U/mL,carbohydrate antigen 199 was(41.39±3.27)U/mL,carbohydrate antigen 724 was(9.21±1.05)U/mL,which were lower than those of control group(8.53±1.25)ng/mL,(35.41±2.19)U/mL,(46.58±4.05)U/mL,(14.38±1.67)U/mL,and the differences were statistically significant(t=9.337,16.769,6.836,17.968,all P<0.001).

关 键 词：胃癌 SOX化疗 复元和中汤 穴位贴敷 T淋巴细胞亚群 肿瘤标志物 不良反应 

分 类 号：R246.5[医药卫生—针灸推拿学]