富血小板血浆联合Wiltse肌间隙入路伤椎置钉内固定治疗胸腰椎骨折的临床疗效观察  

Clinical Effect of Platelet-rich Plasma Combined with Screw Internal Fixation of Injured Vertebrae Through Wiltse Intermuscular Approach in the Treatment of Thoracolumbar Fracture

作　　者：侯平选 Hou Pingxuan(The Second Ward of Department of Orthopedics,Nanyang Second General Hospital of Henan Province,Nanyang,Henan,473000,China)

机构地区：[1]南阳市第二人民医院骨科二病区,河南南阳473000

出　　处：《黑龙江医学》2024年第23期2866-2868,共3页Heilongjiang Medical Journal

摘　　要：目的:观察富血小板血浆(PRP)联合Wiltse肌间隙入路伤椎置钉内固定治疗胸腰椎骨折(TLF)的临床疗效。方法:选取2022年2月—2023年2月南阳市第二人民医院收治的84例TLF患者作为研究对象,采用单双号分组法将其分为对照组和观察组,每组各42例。两组患者均行Wiltse肌间隙入路伤椎置钉内固定治疗,观察组在手术治疗基础上接受PRP注射治疗。比较两组患者手术、术后康复、炎症反应、过氧化反应相关指标。结果:观察组下床活动时间、骨折愈合时间更短,差异有统计学意义(t=6.895、7.896,P<0.05);观察组术后1个月、3个月、6个月时视觉模拟评分量表(VAS)评分、Oswestry功能障碍指数(ODI)均低于对照组,差异有统计学意义(t=11.008、4.717、4.348、6.008、8.347、6.332,P<0.05);术后1个月,观察组白介素-7受体(IL-7R)、白介素-6(IL-6)、丙二醛(MDA)水平均低于对照组,超氧化物歧化酶(SOD)水平高于对照组,差异有统计学意义(t=14.962、12.736、8.243、7.455,P<0.05)。结论:PRP联合Wiltse肌间隙入路伤椎置钉内固定治疗TLF临床效果较好,可进一步改善患者术后炎症反应和过氧化反应,对加快患者术后恢复、减轻术后疼痛、促进腰椎功能恢复有重要意义。Objective:To observe the clinical effect of platelet-rich plasma(PRP)combined with screw internal fixation of injured vertebrae through wiltse intermuscular approach in the treatment of thoracolumbar fracture(TLF).Methods:A total of 84 patients with TLF admitted to the hospital from February 2022 to February 2023 were divided into control group(n=42)and observation group(n=42)with odd-even grouping method.The two groups were treated with screw internal fixation of injured vertebrae through Wiltse intermuscular approach.The observation group was treated with PRP injection on the basis of surgical treatment.The indexes related to operation,postoperative rehabilitation,inflammatory response and peroxidatic reaction were compared between the two groups.Results:The time of getting out of bed and the time of fracture healing were shorter in the observation group,with statistically significant difference(t=6.895,7.896;P<0.05).1 month,3 months and 6 months after surgery,the visual analogue scale(VAS)scores and Oswestry Disability Index(ODI)scores of the observation group were lower than the control group,with statistically significant difference(t=11.008,4.717,4.348,6.008,8.347,6.332;P<0.05).1 month after operation,the levels of interleukin-7 receptor(IL-7R),interleukin-6(IL-6)and malondialdehyde(MDA)in the two groups decreased,while the level of superoxide dismutase(SOD)increased,and the changes in the observation group were greater,with statistically significant difference(t=14.962,12.736,8.243,7.455;P<0.05).Conclusion:PRP combined with screw internal fixation of injured vertebrae through wiltse intermuscular approach for the treatment of TLF has good clinical effect,which can further improve the postoperative inflammatory response and peroxidatic reaction of patients,accelerate the postoperative recovery of patients,reduce postoperative pain,and promote the recovery of lumbar function.

关 键 词：胸腰椎骨折 Wiltse肌间隙入路 伤椎置钉内固定 富血小板血浆 术后疼痛 腰椎功能 

分 类 号：R687.3[医药卫生—骨科学]