绝经后骨质疏松患者血清miR-27b-3p的表达及意义  

Expression and significance of serum miR-27b-3p in patients with postmenopausal osteoporosis

作　　者：叶佰盛 袁一峰 周航 黄振 黄旭东 李金坤 史晓林 唐彬彬 YE Baisheng;YUAN Yifeng;ZHOU Hang;HUANG Zhen;HUANG Xudong;LI Jinkun;SHI Xiaoin;TANG Binbin(The Second School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China;Department of Orthopedics,the Second Affiliated Hospital,Zhejiang Chinese Medical University,Hangzhou 310000,Zhejiang,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江中医药大学附属第二医院骨科,浙江杭州310000

出　　处：《中国现代医生》2024年第34期1-5,共5页China Modern Doctor

基　　金：国家自然科学基金青年项目(82204829);浙江省自然科学基金探索项目(LBY22H270005)。

摘　　要：目的探讨绝经后女性血清miR-27b-3p与Ⅰ型前胶原氨基端前肽(N-terminal propeptide of typeⅠprocollagen,PINP)和Ⅰ型胶原C末端肽1(C-terminal telopeptide of typeⅠcollagen 1,CTX-1)的相关性。方法选取2022年2月至2023年2月于浙江中医药大学附属第二医院就诊的49例绝经后骨质疏松患者为研究对象,根据测得T值将其分为骨质疏松(osteoporosis,OP)组(T≤–2.5SD,26例)和骨量减少(osteopenia,OPn)组(–2.5SD<T<–1.0SD,23例)。检测并比较两组患者的血清miR-27b-3p、PINP、CTX-1表达水平,分析血清P1NP和CTX-1与miR-27b-3p的相关性。结果OP组患者的血清miR-27b-3p、PINP/CTX-1水平均显著低于OPn组,PINP和CTX-1水平均显著高于OPn组(P<0.05);Pearson分析结果显示,血清PINP和CTX-1水平与miR-27b-3p均呈负相关(P<0.05),PINP/CTX-1与miR-27b-3p呈正相关(P<0.05)。结论血清miR-27b-3p水平可作为绝经后女性骨形成的潜在标志物。Objective To investigate the correlation between serum miR-27b-3p and N-terminal propeptide of typeⅠprocollagen(PINP)and C-terminal telopeptide of typeⅠcollagen 1(CTX-1)in postmenopausal women.Methods Forty-nine patients with postmenopausal osteoporosis treated in the Second Affiliated Hospital,Zhejiang Chinese Medical University from February 2022 to February 2023 were selected as study objects.They were divided into osteoporosis(OP)group(T≤–2.5SD,26 cases)and osteopenia(OPn)group(–2.5SD<T<–1.0SD,23 cases).The expression levels of serum miR-27b-3p,PINP and CTX-1 in two groups were detected and compared,and the correlation between serum P1NP and CTX-1 and miR-27b-3p was analyzed.Results The levels of serum miR-27b-3p and PINP/CTX-1 in OP group were significantly lower than those in OPn group,and the levels of PINP and CTX-1 were significantly higher than those in OPn group(P<0.05).Pearson analysis showed that serum PINP and CTX-1 levels were negatively correlated with miR-27b-3p(P<0.05),while PINP/CTX-1 was positively correlated with miR-27b-3p(P<0.05).Conclusion Serum miR-27b-3p levels may serve as a potential marker for bone formation in postmenopausal women.

关 键 词：miR-27b-3p 骨代谢 绝经后骨质疏松 Ⅰ型前胶原氨基端前肽 Ⅰ型胶原C末端肽1 

分 类 号：R274.9[医药卫生—中西医结合]