心脉隆注射液对冠心病心力衰竭患者心功能及血清炎症指标的影响  

Influence of Xinmailong injection on cardiac function and serum inflammatory indexes in patients with coronary heart disease and heart failure

作　　者：唐佳佳 陈静静 徐羽蒙 缪雄 TANG Jia-jia;CHEN Jing-jing;XU Yu-meng;MIAO Xiong(Pharmacy Department,Hai'an People's Hospital,Nantong,Jiangsu,226600,China)

机构地区：[1]海安市人民医院药剂科,江苏南通226600 [2]海安市人民医院心内科,江苏南通226600 [3]如东县栟茶镇中心卫生院

出　　处：《心血管康复医学杂志》2024年第6期757-761,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨心脉隆注射液对冠心病心力衰竭患者心功能及血清炎症指标的影响。方法:选取2019年8月~2020年7月海安市人民医院收治的150例冠心病心力衰竭患者,按随机数字表法将其分为对照组(n=75)及联合治疗组(n=75)。对照组采取常规抗心衰治疗,联合治疗组在此基础上联合心脉隆注射液治疗。治疗7d后,比较两组临床疗效、症状改善时间、心功能、血清炎症指标及不良反应情况。结果:联合治疗组患者治疗总有效率显著高于对照组(93.33%比80.00%,P=0.016)。与对照组比较,联合治疗组患者治疗后肺啰音、全身水肿及呼吸困难等症状改善时间均显著缩短,心输出量(CO)、左室射血分数(LVEF)、6min步行距离(6MWD)和血管内皮生长因子(VEGF)水平均显著升高,左室舒张末期内径(LVEDd)显著减小,N末端B型利钠肽前体(NT-proBNP)和高敏C反应蛋白(hsCRP)水平均显著降低(P均<0.001)。两组治疗期间均未发现明显不良反应。结论:常规抗心衰治疗联合心脉隆注射液不仅能有效改善冠心病心力衰竭患者心功能,同时还能减轻炎症,临床疗效及安全性均较佳。Objective:This study aims to investigate the influence of Xinmailong injection on cardiac function and serum inflammatory indexes in patients with coronary heart disease(CHD)and heart failure(HF).Methods:This randomized controlled study enrolled 150 CHD+HF patients admitted in Hai'an People's Hospital between August 2019 and July 2020.They were divided into control group(n=75,routine anti-HF therapy)and combined treatment group(n=75,Xinmailong injection treatment based on control group).After 7d treatment,clinical therapeutic effect,symptom improvement time,cardiac function,serum inflammatory indexes and incidence of adverse reactions were compared between two groups.Results:The total effective rate in combined treatment group was significantly higher than that of control group(93.33%vs.80.00%,P=0.016).Compared with patients in control group after treatment,those in combined treatment group had significant shorter improvement time of pulmonary rales,systemic edema and dyspnea,significant higher cardiac output(CO),left ventricular ejection fraction(LVEF),6min walking distance(6MWD)and vascular endothelial growth factor(VEGF)level,and significant lower left ventricular end-diastolic diameter(LVEDd),levels of N terminal pro brain natriuretic peptide(NT-proBNP)and high sensitive C reactive protein(hsCRP)(P<0.001 all).We detected no obvious adverse reactions in two groups during treatment.Conclusion:Routine anti-HF treatment combined with Xinmailong injection could not only effectively improve cardiac function,but also relieve inflammation in patients with coronary heart disease and heart failure,and its clinical efficacy and safety are both good.

关 键 词：冠心病 心力衰竭 心脉隆注射液 炎症 

分 类 号：R541.4[医药卫生—心血管疾病]