胺碘酮联合美托洛尔对急性心肌梗死合并心律失常患者心电图指标及血清GDF-15、Gal-3水平的影响  

Effects of amiodarone combined with metoprolol on electrocardiogram indexes and serum levels of GDF-15 and Gal-3 in patients with acute myocardial infarction complicated with arrhythmia

作　　者：张水宝 张洪宇 李果[1] 王瑾[3] 张晓丹 梁金花[1] ZHANG Shuibao;ZHANG Hongyu;LI Guo;WANG Jin;ZHANG Xiaodan;LIANG Jinhua(Department of General Medicine,Puyang People′s Hospital,Puyang,Henan 457000,China;Department of Cardiology,Chinese Medicine Hospital of Puyang,Puyang,Henan 457000,China;Department of Cardiology,Puyang People's Hospital,Puyang,Henan 457000,China;Department of Cardiology,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou,Henan 450011,China)

机构地区：[1]濮阳市人民医院全科医学科,河南濮阳457000 [2]濮阳市中医院心内科,河南濮阳457000 [3]濮阳市人民医院心内科,河南濮阳457000 [4]河南省中医院心内科,河南郑州450011

出　　处：《现代医药卫生》2024年第23期4036-4040,共5页Journal of Modern Medicine & Health

摘　　要：目的探讨分析胺碘酮(AD)联合美托洛尔(MP)对急性心肌梗死合并心律失常患者心电图指标及血清生长分化因子-15(GDF-15)、半乳糖凝集素-3(Gal-3)水平的影响。方法选取2020年7月至2023年8月濮阳市人民医院和濮阳市中医院收治的急性心肌梗死合并心律失常患者126例,采用简单随机分组法分为AD组(AD治疗)和MP联合组(AD联合MP治疗),每组63例。2组患者均持续治疗2个月。比较2组患者临床疗效,治疗前后心脏功能[包括左心室舒张末期内径(LVDD)、左心室收缩功能不全(LVSD)和左心室射血分数(LVEF)]、心电图指标,以及血清GDF-15、Gal-3、炎症因子水平和不良反应发生率。结果MP联合组患者总有效率明显高于AD组[96.83%(61/63)vs.87.30%(55/63)],差异有统计学意义(P<0.05);2组患者治疗2个月后LVDD、LVSD,以及血清CDF-15、Gal-3、炎症因子水平均较治疗前明显降低,LVEF、心电图指标较治疗前明显升高,且MP联合组患者治疗2个月后LVDD、LVSD,以及血清CDF-15、Gal-3、炎症因子水平均明显低于AD组,LVEF、心电图指标均明显高于AD组,差异均有统计学意义(P<0.05);2组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论AD与MP联合使用临床疗效较好,可明显改善患者心电图指标和心功能水平,降低血清GDF-15、Gal-3、炎症因子水平。Objective To investigate the effects of amiodarone(AD)combined with metoprolol(MP)on electrocardiogram indexes and serum growth differentiation factor-15(GDF-15)and galectin-3(Gal-3)levels in patients with acute myocardial infarction complicated with arrhythmia.Methods A total of 126 patients with acute myocardial infarction complicated with arrhythmia admitted to Puyang People′s Hospital and Chinese Medicine Hospital of Puyang from July 2020 to August 2023 were selected and divided into AD group(AD treatment)and MP combined group(AD combined with MP treatment)by simple random grouping method,with 63 cases in each group.Patients in both groups were treated for two months.The clinical efficacy,cardiac function[including left ventricular end-diastolic diameter(LVDD),left ventricular systolic dysfunction(LVSD)and left ventricular ejection fraction(LVEF)],electrocardiogram indexes,serum levels of GDF-15,Gal-3,inflammatory factors and incidence of adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the MP combined group was significantly higher than that of the AD group[96.83%(61/63)vs.87.30%(55/63)],and the difference was statistically significant(P<0.05).After two months of treatment,the levels of LVDD,LVSD,serum CDF-15,Gal-3 and inflammatory factors in the two groups were significantly lower than those before treatment,and the LVEF and electrocardiogram indexes were significantly higher than those before treatment.After two months of treatment,the levels of LVDD,LVSD,serum CDF-15,Gal-3 and inflammatory factors in the MP combined group were significantly lower than those in the AD group,and the LVEF and electrocardiogram indexes were significantly higher than those in the AD group,the differences were statistically significant(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of AD and MP2 has a good clinical effect,which can signi

关 键 词：胺碘酮 美托洛尔 急性病 心肌梗死 心律失常 心电图 生长分化因子-15 半乳糖凝集素-3 

分 类 号：R542.22[医药卫生—心血管疾病] R541.7[医药卫生—内科学]