细菌转录终止的分子机制研究进展  

Progress on molecular mechanisms of bacterial transcription termination

作　　者：尤琳琳 张余 Linlin You;Yu Zhang(Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Shanghai 200032,China;University of Chinese Academy of Sciences,Beijing 100049,China;Waksman Institute of Microbiology,Rutgers University,Piscataway,NJ 08854,USA)

机构地区：[1]中国科学院分子植物科学卓越创新中心,中国科学院合成生物学重点实验室,上海200032 [2]中国科学院大学,北京100049 [3]罗格斯大学,瓦克斯曼微生物研究所,皮斯卡特维08854,美国

出　　处：《遗传》2024年第12期982-994,共13页Hereditas（Beijing)

基　　金：上海市基础研究特区计划(编号:JCYJ-SHFY-2022-012);国家重点研发计划(编号:2018YFA0903701);中国科学院先导科技专项(编号:CAS XDB29020000)资助。

摘　　要：转录是遗传信息从DNA传递成RNA的过程,主要分为转录起始、转录延伸和转录终止3个阶段。转录终止是基因转录的最后一步,对基因表达的准确性至关重要。细菌的转录终止主要有两种形式:依赖于Rho因子的转录终止和固有转录终止(即不依赖于Rho因子的转录终止)。细菌转录终止过程受到细菌或噬菌体蛋白的正向和反向调控。本文主要总结了细菌转录终止机制和调控的研究进展,以期为进一步研究、理解转录终止过程提供理论基础。Transcription is the process by which genetic information is copied from DNA to RNA,and it can be divided into three stages:transcription initiation,elongation,and termination.Transcription termination is the last step of gene transcription and is crucial for accurate gene expression.Two prevailing modes of transcription termination exist in bacteria:Rho-dependent termination and intrinsic termination(Rho-independent termination).Transcription termination is positively and negatively regulated by bacterial or bacteriophage proteins.In this review,we summarize the research progress of bacterial transcription and its regulation,with the aim of providing a theoretical foundation for further studies and understanding of transcription termination process.

关 键 词：转录 RNA聚合酶 转录终止 转录调控 

分 类 号：Q933[生物学—微生物学]