基于巨噬细胞极化理论探讨中医药防治钙化性主动脉瓣疾病  

Exploring the Prevention and Treatment of Calcific Aortic Valve Disease with Traditional Chinese Medicine Based on Macrophage Polarization Theory

作　　者：杜梦辉 冯娟 高爱社[1] 程凯[1] 张炅[1] 王坦[1] 张昊一 陈芳[1] DU Menghui;FENG Juan;GAO Aishe;CHENG Kai;ZHANG Jiong;WANG Tan;ZHANG Haoyi;CHEN Fang(Department of Medical School,Henan University of Chinese Medicine,Zhengzhou 450046 Henan,China)

机构地区：[1]河南中医药大学医学院,河南郑州450046

出　　处：《中药新药与临床药理》2024年第12期1937-1943,共7页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(81904050,82474316)。

摘　　要：钙化性主动脉瓣疾病(CAVD)是一种进行性心脏瓣膜病,其发病机制与动脉粥样硬化相似,涉及脂质沉积、炎症反应和细胞外基质重塑等途径。炎症反应在CAVD的发病机制中起着关键作用,而巨噬细胞作为炎症反应的核心执行者,其极化状态与疾病进展息息相关。中医理论认为,巨噬细胞极化状态与阴阳学说有着密切联系。该文介绍了巨噬细胞不同极化状态下对CAVD的影响,以及中医药通过多途径调控巨噬细胞极化防治CAVD的作用和机制,为中医药治疗CAVD提供新思路。Calcific aortic valve disease(CAVD)is a progressive heart valve disorder,which has similar pathogenesis of atherosclerosis,involving lipid deposition,inflammatory response,and extracellular matrix remodeling.Inflammation plays a crucial role in the pathogenesis of CAVD.Macrophages as central executors of the inflammatory response,whose polarization state is closely related to disease progression.Traditional Chinese medicine(TCM)theory suggests a close connection between macrophage polarization and yin-yang theory.This paper introduces the effect of macrophage with different polarization states on CAVD,as well as the role and mechanisms of TCM in regulating macrophage polarization to prevent and treat CAVD through muti-pathway,aiming to provide new insights for the treatment of CAVD with TCM.

关 键 词：钙化性主动脉瓣疾病 中医药 巨噬细胞极化 炎症 

分 类 号：R285.5[医药卫生—中药学]