青中年气滞痰瘀人群与甲状腺结节的相关性研究  

Correlation Between Qi Stagnation and Phlegm Stasis Syndrome in Young and Middle-Aged Population and the Prevalence of Thyroid Nodules

作　　者：温春图 张继峰[2] 周正[2] 罗小倩 冯骏杰 WEN Chun-Tu;ZHANG Ji-Feng;ZHOU Zheng;LUO Xiao-Qian;FENG Jun-Jie(Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Dongguan Hospital of Guangzhou University of Chinese Medicine,Dongguan 523000 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510006 [2]广州中医药大学东莞医院,广东东莞523000

出　　处：《广州中医药大学学报》2024年第12期3110-3114,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20221421);张继峰东莞市名中医药专家传承工作室项目(东卫函〔2020〕136号)。

摘　　要：【目的】探究青中年气滞痰瘀人群与检出甲状腺结节的联系。【方法】收集2023年6月1日至2023年12月1日在广州中医药大学东莞医院参加问卷调查和甲状腺超声检查者的资料,包括年龄、性别、家族史、体质量指数(BMI)、各种相关症状、超声结果等信息,对相关数据进行统计学分析。【结果】(1)共收集196例受调查者的临床资料,其中,甲状腺结节患者65例(33.16%),气滞痰瘀证候人群50例(25.51%),气郁质人群53例(27.04%),血瘀质人群55例(28.06%),痰湿质人群48例(24.49%)。(2)单因素分析结果显示,相关因素包括女性、家族史、气滞痰瘀证候、气郁质、血瘀质、痰湿质、头晕头疼、颈项僵硬、吞咽不适、体表肿块、痛经闭经、胸闷、胁胀胁痛、闷闷不乐、情感脆弱、乳房胀痛、面色晦黯、唇色偏黯、黑眼圈、身体沉重、眼睑浮肿、痰多等,差异均有统计学意义(P<0.05或P<0.01)。(3)在单因素分析基础上进行多因素Logistic回归分析,结果显示:气滞痰瘀证候(OR:4.03,95%CI:1.85~8.77)、痰湿质(OR:4.68,95%CI:2.06~10.63)、体表肿块(OR:2.97,95%CI:1.11~7.95)是甲状腺结节的影响因素。(4)依此构建检出甲状腺结节的预测模型:logi(t P)=-1.607+1.39×气滞痰瘀证候(0:否,1:是)+1.54×痰湿质(0:否,1:是)+1.09×体表肿块(0:否,1:是);采用受试者工作特征(ROC)曲线评估该模型,曲线下的面积(AUC)为0.75(95%CI:0.67~0.83,P<0.001)。【结论】在青中年人群中,气滞痰瘀与发现甲状腺结节相关,是其危险因素。对气滞痰瘀人群的早期识别、风险预测和及时干预可能对甲状腺结节疾病的防治有重要意义。Objective To investigate the correlation between qi stagnation and phlegm stasis syndrome in the young and middle-aged population and the detection rate of thyroid nodules.Methods The clinical data of those who participated in the questionnaire survey and took thyroid ultrasonography at Dongguan Hospital of Guangzhou University of Chinese Medicine from June 1 to December 1,2023 were collected.The clinical information covered age,gender,family history,body mass index(BMI),related symptoms,and ultrasonographic findings.And then the related data were statistically analyzed.Results(1)The clinical data of 196 cases were collected,of which 65 cases(33.16%)suffered from thyroid nodules,50 cases(25.51%)were differentiated as qi stagnation and phlegm stasis syndrome,53 cases(27.04%)had qi depression constitution of traditional Chinese medicine(TCM),55 cases(28.06%)had blood stasis constitution,and 48 cases(24.49%)had phlegm-dampness constitution.(2)The results of univariate analysis showed that the relevant factors for thyroid nodules included female,family history,qi stagnation and phlegm stasis syndrome,qi depression constitution,blood stasis constitution,phlegm-dampness constitution,dizziness and headache,neck stiffness,swallowing discomfort,lump on the surface of the body,dysmenorrhea and amenorrhea,tightness in the chest,distending pain in hypochondrium,depressed in spirits,emotional vulnerability,distending pain in breast,gloomy complexion,darkish lips,dark circles around the eyes,heaviness of the body,eyelid edema,and profuse sputum,and the differences were all statistically significant(P<0.05 or P<0.01).(3)Multivariate Logistic regression analysis was performed on the basis of univariate analysis,and the results showed that qi stagnation and phlegm stasis syndrome(OR:4.03,95%CI:1.85-8.77),phlegm-dampness constitution(OR:4.68,95%CI:2.06-10.63),and lump on the surface of the body(OR:2.97,95%CI:1.11-7.95)were the influencing factors for thyroid nodules.(4)A prediction model for detecting thyroid nodules was construct

关 键 词：甲状腺结节 气滞痰瘀 青中年 中医体质 早期识别 风险预测 

分 类 号：R265[医药卫生—中医外科学]