针刺联合紫萸补肾益气调经汤治疗多囊卵巢综合征的临床观察  

Clinical Observation on Acupuncture Combined with Zi Yu Bushen Yiqi Tiaojing Decoction in the Treatment of Polycystic Ovary Syndrome

作　　者：李霞 赵利堂 谢玲 LI Xia;ZHAO Li-Tang;XIE Ling(Jinan Zhangqiu Maternal and Child Health Hospital,Jinan 250200 Shandong,China)

机构地区：[1]济南市章丘区妇幼保健院,山东济南250200

出　　处：《广州中医药大学学报》2024年第12期3216-3222,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：山东省中医药科技项目(编号:2020M178)。

摘　　要：【目的】观察针刺联合紫萸补肾益气调经汤治疗多囊卵巢综合征(PCOS)的临床疗效及对卵巢储备功能和性激素水平的影响。【方法】将60例肾虚痰湿型PCOS患者随机分为观察组和对照组,每组各30例,对照组给予常规西药治疗,观察组在对照组治疗的基础上,给予针刺联合紫萸补肾益气调经汤治疗。2组均治疗6个月。治疗6个月后,评价2组临床疗效,观察2组患者治疗前后中医证候积分的变化情况,以及患者睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)水平的情况。比较2组患者治疗前后抗苗勒管激素(AMH)、窦状卵泡数目(AFC)的变化情况,以及子宫内膜厚度、卵巢体积与宫颈评分的情况。并评价2组的安全性及1年后自然妊娠率。【结果】(1)治疗后,2组患者的中医证候积分均明显改善(P<0.05),且观察组在改善中医证候积分方面明显优于对照组,差异均有统计学意义(P<0.05)。(2)治疗后,2组患者的AFC、AMH水平明显改善(P<0.05),且观察组在改善AFC、AMH水平方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的T、LH、FSH水平明显改善(P<0.05),且观察组在改善T、LH、FSH水平方面明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗后,2组患者的子宫内膜厚度、卵巢体积、宫颈评分水平均明显改善(P<0.05),且观察组在改善子宫内膜厚度、卵巢体积、宫颈评分水平方面明显优于对照组,差异有统计学意义(P<0.05)。(5)观察组总有效率为96.67%(29/30),对照组为73.33%(22/30)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(6)观察组与对照组在治疗期间不良反应发生率分别为6.67%(2/30)与33.33%(10/30),差异无统计学意义(P>0.05)。1年后,观察组与对照组自然妊娠率分别为60.00%(18/30)与33.33%(10/30),观察组自然妊娠率明显高于对照组,差异有统计学意义(P<0.05)。【结论】针刺联合紫萸补肾益气调经汤治疗PCOObjective To observe the clinical efficacy of acupuncture combined with Zi Yu Bushen Yiqi Tiaojing Decoction in the treatment of polycystic ovary syndrome(PCOS)and its effect on ovarian reserve function and sex hormone level.Methods Sixty patients with PCOS of phlegm-damp due to kidney deficiency type were randomly divided into observation group and control group,30 patients in each group,the control group was treated with conventional western medicines,and the observation group was treated with acupuncture combined with Zi Yu Bushen Yiqi Tiaojing Decoction on the basis of treatment of the control group.Both groups were treated for six months.After six months of treatment,the clinical efficacy of the two groups was evaluated,and the changes of traditional Chinese medicine(TCM)syndrome scores and the levels of testosterone(T),luteinizing hormone(LH)and follicle stimulating hormone(FSH)of the two groups of patients were observed before and after treatment.The changes of anti-Mullerian hormone(AMH),antral follicle count(AFC),as well as endometrial thickness,ovarian volume and cervical score before and after treatment between the two groups of patients were compared.The safety of the two groups and the natural pregnancy rate after one year follow-up were evaluated.Results(1)After treatment,the TCM syndrome scores of patients in the two groups were significantly improved(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,and the differences were all statistically significant(P<0.05).(2)After treatment,the AFC and AMH levels of patients in the two groups were improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,and the difference was statistically significant(P<0.05).(3)After treatment,the levels of T,LH and FSH of patients in the two groups were improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,with sta

关 键 词：针刺 紫萸补肾益气调经汤 多囊卵巢综合征 卵巢储备 性激素 

分 类 号：R246.9[医药卫生—针灸推拿学]