肉桂醛肟酯衍生物的设计、合成及抑菌活性  

Design,synthesis and antifungal activity of cinnamaldehyde oxime ester derivatives

作　　者：刘夷宁 袁含笑 胡钰歌 林涵 李秀环 雷鹏 LIU Yining;YUAN Hanxiao;HU Yuge;LIN Han;LI Xiuhuan;LEI Peng(College of Plant Protection,Northwest A&F University,Yangling 712100,Shaanxi Province,China;State Key Laboratory for Crop Stress Resistance and High-Efficiency Production,Yangling 712100,Shaanxi Province,China;Shaanxi Research Center of Biopesticide Engineering&Technology,Yangling 712100,Shaanxi Province,China)

机构地区：[1]西北农林科技大学植物保护学院,陕西杨凌712100 [2]作物抗逆与高效生产全国重点实验室,陕西杨凌712100 [3]陕西省生物农药工程技术研究中心,陕西杨凌712100

出　　处：《农药学学报》2024年第6期1053-1060,共8页Chinese Journal of Pesticide Science

基　　金：陕西省重点研发计划(2023-YBNY-244);大学生创新创业训练计划项目(20240026058)。

摘　　要：天然产物肉桂醛具有良好的生物活性,为丰富其结构并发现高抑菌活性化合物,设计、合成了未见文献报道的肉桂醛肟酯衍生物27个,采用菌丝生长速率法测定了目标化合物对水稻纹枯病菌(Rhizoctonia solani)、番茄灰霉病菌(Botrytis cinerea)及小麦全蚀病菌(Gaeumannomyces graminis)的抑制活性。目标化合物在50μg/m L下对供试病原菌均表现出一定的抑制活性,其中化合物II-18和II-19对水稻纹枯病菌的EC50值分别为4.62和4.19μg/m L,化合物II-18、II-19和II-22对小麦全蚀病菌的EC50值分别为3.49、3.28和6.75μg/m L,均表现出比对照药剂对氯肉桂醛和肟菌酯更优或相似的抑菌活性。To enrich cinnamaldehyde's structure and discover highly active antifungal compounds,27 novel cinnamaldehyde oxime esters were designed and synthesized.The antifungal activities of the target compounds against Rhizoctonia solani,Botrytis cinerea,and Gaeumannomyces graminis were determined by the mycelium growth rate method.The target compounds showed certain inhibitory activity against the tested pathogenic fungi under 50μg/mL.The EC50 values of compounds II-18 and II-19 against Rhizoctonia solani were 4.62 and 4.19μg/mL,respectively.Furthermore,the EC50 values of II-18,II-19 and II-22 against Gaeumannomyces graminis were 3.49,3.28 and 6.75μg/mL,respectively,which showed superior or comparable antifungal activities to those of 4-chlorocinnamaldehyde and trifloxystrobin.

关 键 词：肉桂醛 肟酯 杀菌活性 水稻纹枯病菌 小麦全蚀病菌 

分 类 号：TQ450.1[化学工程—农药化工]