沸石咪唑酸酯骨架-8负载二氯吡啶酸纳米载药体系制备及性能研究  

Preparation and performance study of zeolitic imidazolate frameworks-8 loaded clopyralid nanoparticle drug delivery system

作　　者：蔡润泽 黄啟良[2] 潘灿平[1] 赵鹏跃 CAI Runze;HUANG Qiliang;PAN Canping;ZHAO Pengyue(Collage of Science,China Agricultural University,Beijing 100193,China;Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]中国农业大学理学院,北京100193 [2]中国农业科学院植物保护研究所,北京100193

出　　处：《农药学学报》2024年第6期1094-1104,共11页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金(32372599)。

摘　　要：二氯吡啶酸是一种激素型杂环类除草剂,已被广泛用于防治油菜、玉米、小麦等田间的阔叶杂草。由于二氯吡啶酸可溶于水且容易移动,目前已被认定为农业废水中一种重要的新型污染物。将二氯吡啶酸制备成缓控释剂型有望降低其对环境的负面影响。本研究以沸石咪唑酸酯骨架-8(ZIF-8)作为载体材料制备了二氯吡啶酸@ZIF-8纳米载药体系,并对负载方法进行了优化以提高载药量,通过透射电镜、动态光散射、X射线衍射、傅里叶变换红外光谱、热重分析、N_(2)吸附-脱附对其形貌、粒径分布、化学官能团、晶体结构、热稳定性等指标进行了表征,并研究了其释放机制与除草活性。结果表明:二氯吡啶酸可成功负载到ZIF-8载体中,载药后粒径约为219.3 nm,载药量最高可达43.6%,其释放模式最符合Weibull模型(R^(2)=0.9999)。生物活性测定表明,将二氯吡啶酸负载到ZIF-8后不会降低其对稗草的除草活性,甚至在高浓度下,ZIF-8负载还能起到一定的增效作用。本研究可为基于ZIF-8载体的除草剂载药体系制备提供参考。Clopyralid is a hormone-type heterocyclic herbicide that has been widely used to control broad-leaved weeds in crops such as rapeseed,corn,and wheat.However,clopyralid is water soluble and mobile,and it has been recognized as a new type of pollutant in agricultural wastewater.The preparation of sustained-release formulations of clopyralid can effectively reduce its negative impact on the environment.This study prepared a clopyralid loading system using zeolitic imidazolate frameworks-8(ZIF-8)as a carrier and optimized the loading method.The morphology,size distribution,chemical functional groups,crystal structure,thermal stability and other indicators were characterized by transmission electron microscopy,dynamic light scattering,X-ray diffraction,Fourier transform infrared spectroscopy,thermogravimetric analysis,and N_(2)adsorption desorption.The release mechanism and herbicidal activity were also studied.The results showed that clopyralid could be successfully loaded into the ZIF-8 carrier,with the particle size being approximately 219.3 nm after loading with clopyralid.The drug loading rate reached a maximum of 43.6%,and its release mode was most consistent with the Weibull model(R^(2)=0.9999).Additionally,the results of bioactivity experiment against Echinochloa crus-galli showed that the herbicidal activity of clopyralid was not reduced after loading into ZIF-8,and even at a high concentration,ZIF-8 could play a certain synergistic effect.This study provided a reference for the preparation of herbicide loading systems based on ZIF-8 carrier.

关 键 词：二氯吡啶酸 沸石咪唑酸酯骨架-8 纳米载药体系 制备方法 稗草 

分 类 号：TQ450.6[化学工程—农药化工] S482.4[农业科学—农药学]