Application of Norway Spruce Leaf Extract in Oily Skin Care:A Mechanism and Clinical Study  

作　　者：Zhang Jianhua Liu Shichao Guo Wenjiao Li Na Zhang Jianhua Liu Shichao[2] Guo Wenjiao[2] 

机构地区：[1]N.O.D topia(GuangZhou)Biotechnology Co.,Ltd.,China [2]Simpcare(GuangZhou)Biotechnology Co.,Ltd.,China

出　　处：《China Detergent & Cosmetics》2024年第4期58-63,共6页日用化学品科学（英文版）

摘　　要：Oily skin,a facial skin condition,appears shiny and greasy and is a source of common skin disorders such as acne vulgaris and seborrheic dermatitis.Moreover,oily skin can lead to depression,distress,and so on,which can be detrimental to social interactions.In this study,the effect of Norway spruce leaf extract(NSLE)on the management of oily skin was investigated both in vitro and in vivo,focusing on its sebum-controlling and anti-inflammatory properties.The in vitro results showed that the NSLE significantly reduced neutral lipids in linoleic acid(LA)-induced human SZ95 sebocytes in a dose-dependent manner(P<0.05).Additionally,the 2.5%NSLE was able to reduce the lipopolysaccharide(LPS)-induced elevation of nitric oxide(NO)levels in RAW264.7 cells(P<0.05).The human efficacy evaluation showed that the emulsion containing 2.5%NSLE had a significant sebum-controlling effect,the skin sebum content decreased by 29.3%after 7 days.Furthermore,the results also indicated a notable improvement in skin glossiness and lightness(P<0.05)after two weeks of application,compared to baseline.In conclusion,NSLE effectively enhances the skin health of oily skin by reducing sebum production and inhibiting inflammation.This study provided evidence for NSLE as a natural and effective ingredient in skincare products for individuals with oily skin.

关 键 词：Norway spruce leaf oily skin sebum-controlling ANTI-INFLAMMATORY 

分 类 号：TQ658[化学工程—精细化工]