Characterization and Implications of the Regionally Prevalent ST8333 Strains of Salmonella enterica Serotype 4,[5],12:i:-China,2017-2023  

作　　者：Qingpo Cui Xiaorong Yang Tingting Yang Xin Wang Xin Ma Yuxia Liu Hua Ge Xin Qiao Mengjiao Fu Yunchang Guo Zhangqi Shen Weiwei Li 

机构地区：[1]Technology Innovation Center for Food Safety Surveillance and Detection(Hainan),Sanya Institute of China Agricultural University,Sanya City,Hainan Province,China [2]Sichuan Provincial Center for Disease Control and Prevention,Chengdu City,Sichuan Province,China [3]Department of Gastroenterology,The Eighth Medical Center,PLA General Hospital,Beijing,China [4]Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region,Urumqi City,Xinjiang Uygur Autonomous Region,China [5]Xinjiang Production and Construction Corps Center for Disease Prevention and Control,Urumqi City,Xinjiang Uygur Autonomous Region,China [6]Qinghai Center for Disease Prevention and Control,Xining City,Qinghai Province,China [7]Jiangsu Provincial Center for Disease Control and Prevention,Nanjing City,Jiangsu Province,China [8]National Health Commission Key Laboratory of Food Safety Risk Assessment,Chinese Academy of Medical Science Research Unit(No.2019RU014),China National Center for Food Safety Risk Assessment,Beijing,China

出　　处：《China CDC weekly》2024年第47期1232-1235,共4页中国疾病预防控制中心周报（英文）

基　　金：Supported by the National Key Research and Development Program of China(Grant No.2022YFC2303900);along with the National Natural Science Foundation of China(Grant Nos.32141001 and 32225048).

摘　　要：What is already known about this topic?Salmonella enterica is a significant foodborne pathogen responsible for millions of infections and thousands of deaths worldwide each year.The increasing prevalence of the ST34 Salmonella enterica serotype 4,5,12:i:-(S.4,[5],12:i:-)poses a substantial public health threat in China.What is added by this report?At the end of 2023,the TraNet early-warning module,utilizing whole-genome sequencing data,identified a newly regionally prevalent sequence type of S.4,[5],12:i:-,designated ST8333,primarily found in Sichuan Province.Analysis revealed high rates of antimicrobial resistance genes,particularly to aminoglycosides andβ-lactams.Plasmid comparisons suggest that ST8333 isolates acquired multidrugresistance plasmids of swine origin during their distribution in Sichuan Province.What are the implications for public health practice?The emergence of ST8333,likely associated with pork consumption,underscores the importance of food safety measures.The high prevalence of multidrug resistance poses challenges for treatment and highlights the need for vigilant surveillance and control measures.Strengthening efforts in regions like Sichuan,identified as a reservoir for multidrug-resistant ST8333 strains,is crucial to prevent further transmission and potential nationwide dissemination.Surveillance and control measures are imperative to curb the spread of multidrug-resistant ST8333 isolates,particularly in high-prevalence regions.

关 键 词：LIKELY RESERVOIR NATIONWIDE 

分 类 号：R516.1[医药卫生—内科学] R181.3[医药卫生—临床医学]