神经生长因子对骨骼形成及骨疾病的影响  

Effects of nerve growth factor on osteogenesis and bone diseases

作　　者：魏鹤翔 孙彬 刘昊[1] 刘含强 夏鹏[1] Wei Hexiang;Sun Bin;Liu Hao;Liu Hanqiang;Xia Peng(Department of Orthopedics,The Second Hospital of Jilin University,Changchun 130000,Jilin Province,China)

机构地区：[1]吉林大学第二医院脊柱外科,吉林省长春市130000

出　　处：《中国组织工程研究》2025年第20期4266-4275,共10页Chinese Journal of Tissue Engineering Research

基　　金：吉林省自然科学基金项目(YDZJ202201ZYTS505),项目负责人:夏鹏;吉林省重点研发计划项目(20230204114YY),项目负责人:夏鹏。

摘　　要：背景:神经生长因子在骨骼的生理和病理进程中发挥了重要作用,系统性分析神经生长因子对骨组织的影响在组织工程及临床治疗两方面都具有重要意义。目的:探究神经生长因子通过骨组织细胞和骨神经-血管耦合等途径调控骨形成的过程,同时研究神经生长因子在骨相关疾病病理进程中的作用。方法:在中国知网、万方、PubMed数据库以“神经生长因子,TrkA,骨,软骨”为中文检索词,以“Nerve growth factor,TrkA,NGF,bone,cartilage”为英文检索词进行文献检索,共检索到2 925篇文献。经过筛选后纳入116篇文献进行归纳总结,撰写综述。结果与结论:神经生长因子既可在骨、软骨、神经、血管等组织细胞中表达,又可作用于这些细胞发挥调控作用。通过多种分泌调控方式,神经生长因子在骨组织内部和骨、神经、血管组织间发挥信号传导作用。通过促进骨髓间充质干细胞的增殖、分化,神经生长因子可促进骨形成及骨修复。神经生长因子介导的破骨细胞生成说明其对骨组织具有多向调控作用。同时,神经生长因子与多种骨科疾病的发生发展高度相关,可能提供新的临床治疗思路。对神经生长因子的研究是了解骨骼生理及病理变化的重要方向之一。BACKGROUND:Nerve growth factor plays an important role in the physiological and pathological processes of bone tissue.Systematic analysis of the effects of nerve growth factor on bone tissue is of great significance in both tissue engineering and clinical treatment.OBJECTIVE:To investigate the regulation of bone formation process by nerve growth factor through pathways such as bone tissue cells and bone nerve-vessel coupling,as well as to study the role of nerve growth factor in the pathological process of bone-related diseases.METHODS:The authors searched for relevant articles in CNKI,WanFang,and PubMed with the keywords of“nerve growth factor,TrkA,NGF,bone,cartilage”in Chinese and English.A total of 2925 articles were initially retrieved.After screening,116 articles were incorporated into this review.RESULTS AND CONCLUSION:Nerve growth factor can be expressed by bone,cartilage,nerve,vessel and other tissue cells.At the same time,nerve growth factor can play a regulatory role on these cells.Through a variety of secretion and regulation methods,nerve growth factor plays a role as a signal transduction factor within bone tissue and between bone,nerve and blood vessel tissues.By promoting the proliferation and differentiation of bone marrow mesenchymal stem cells,nerve growth factor promotes bone formation and bone repair.Nerve growth factor has multi-directional regulatory effects on bone tissue through its effects on osteoclasts.Meanwhile,nerve growth factor is highly correlated with the occurrence and development of many orthopedic diseases and may provide new clinical therapeutic ideas.The study of nerve growth factor is one of the important directions to understand the physiological and pathological processes of bone.

关 键 词：神经生长因子 骨 软骨 关节炎 骨形成 骨修复 神经-血管耦合 骨组织工程 

分 类 号：R459.9[医药卫生—治疗学] R336[医药卫生—临床医学] R681