刺五加抗肿瘤活性成分作用机制及其临床应用  

Research progress on mechanism of action of antitumor active ingredients and clinical application of Acanthopanax senticosus

作　　者：于淼 刘玉龙[1] 王冰 陈刚[5] 薛沁冰[1] 李超宇 王昊 刘婷 陈思宇 YU Miao;LIU Yulong;WANG Bing;CHEN Gang;XUE Qinbing;LI Chaoyu;WANG Hao;LIU Ting;CHEN Siyu(Engineering Research Center for Medicine,Harbin University of Commerce,Harbin 150076,China;School of Food Engineering,Harbin University of Commerce,Harbin 150076,China;Engineering Research Center of Natural Antitumor Drugs,Ministry of Education,Harbin 150076,China;Heilongjiang Provincial Key Laboratory of Cancer Prophylaxis and Anticancer Drugs Research,Harbin 150076,China;Qiqihar Medical University,Qiqihar 161006,China)

机构地区：[1]哈尔滨商业大学药物工程技术研究中心,黑龙江哈尔滨150076 [2]哈尔滨商业大学食品工程学院,黑龙江哈尔滨150076 [3]国家教育部抗肿瘤天然药物工程研究中心,黑龙江哈尔滨150076 [4]黑龙江省肿瘤预防与抗肿瘤药物研究重点实验室,黑龙江哈尔滨150076 [5]齐齐哈尔医学院,黑龙江齐齐哈尔161006

出　　处：《中草药》2024年第22期7897-7906,共10页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省重点研发计划(GZ20220108);2023年度哈尔滨商业大学镜湖学者支持计划项目(JHQNRC06);黑龙江省优秀青年教师基础研究支持计划(YQJH2023243);哈尔滨商业大学博士科研支持计划(24BQ31)。

摘　　要：刺五加Acanthopanax senticosus是五加科传统药用植物,具有益气健脾、补肾安神的功效。现代药理研究表明,刺五加可通过抑制肿瘤细胞增殖、侵袭和转移、阻滞细胞周期、诱导肿瘤细胞凋亡、自噬、提高机体免疫功能等发挥抗肿瘤作用。通过对刺五加抗肿瘤活性成分作用机制及刺五加抗肿瘤的临床应用进行综述,探究其在抗肿瘤应用中的不足和改善策略,旨在揭示刺五加活性成分发挥抗肿瘤作用的具体机制,为刺五加具有抗肿瘤作用的活性成分提供新的认识,提示刺五加抗肿瘤活性成分具有开发成新的抗肿瘤药物的潜力。Ciwujia(Acanthopanax senticosus),a traditional medicinal plant from the Araliaceae family,is known for its functions of invigorating qi,strengthening spleen,tonifying kidney,and calming mind.Modern pharmacological studies have demonstrated that A.senticosus exerts antitumor effects through mechanisms such as inhibiting tumor cell proliferation,invasion,and metastasis,arresting cell cycle,inducing apoptosis and autophagy,and enhancing immune function.This review focuses on mechanisms of action of antitumor active components of A.senticosus and its clinical applications in cancer therapy,aiming to identify existing limitations and propose improvement strategies.The goal is to elucidate the specific mechanisms through which its active ingredients exert antitumor effects,providing new insights into the antitumor potential of A.senticosus and highlighting its potential for developing novel antitumor agents.

关 键 词：刺五加皂苷 刺五加苷 刺五加多糖 细胞凋亡 周期阻滞 抗肿瘤 

分 类 号：R285[医药卫生—中药学]