尿蛋白电泳在浆细胞疾病鉴别诊断中的价值  

The differential diagnosis value of urinary protein electrophoresis in the plasma cell diseases

作　　者：李忠清[1] 罗军[1] Li Zhongqing;Luo Jun(Department of Hematology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院血液内科,南宁530021

出　　处：《中华诊断学电子杂志》2024年第4期217-221,共5页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：国家自然科学基金地区科学基金项目(81660038);广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z2016286)。

摘　　要：许多浆细胞疾病会累及肾脏,导致肾脏功能不同程度受损,笔者将这部分疾病称为肾脏受累的浆细胞疾病(KiPCD)。如何鉴别这一类疾病,持续困扰着很多临床医生。虽然肾穿刺可以协助明确诊断,但其是有创操作,会大大增加患者的诊疗风险。因此临床更需要无创项目,来协助进行鉴别诊断。尿蛋白电泳(uPEP)是一项无创、简单的检查,也是浆细胞疾病诊疗中必不可少的检查。但很多临床医生只关注有无M蛋白以及M蛋白的量,而忽略了其在KiPCD诊断和鉴别诊断中的价值。本文将系统介绍uPEP,以及其在不同KiPCD中的特点,以进一步提高临床对KiPCD的鉴别能力,使更多的患者得到正确的诊断和治疗。Many plasma cell diseases can affect the kidneys,leading to varing degrees of impairment in renal function.Such diseases in this paper will be referred to as kidney involved plasma cell diseases(KiPCD).How to distinguish these diseases continuously puzzled many physicians.Although kidney biopsy can provide a clear diagnosis most of the time,it is an invasive procedure that greatly increases the diagnosis and treatment risks for patients.So non-invasive testing is more needed in clinical practice to assist the differential diagnosis.Urinary protein electrophoresis(uPEP)is a non-invasive and simple examination.It is essential in the diagnosis and treatment of plasma cell diseases.Many physicians focus solely on the presence and amount of M protein while neglecting its value in the diagnosis and differential diagnosis of KiPCD.In order to further improve the clinical ability to distinguish KiPCD and let more patients receive optimal diagnosis and treatment,this article will systematically introduce uPEP and its distinct characteristics in different KiPCD.

关 键 词：尿蛋白电泳 浆细胞疾病 肾病 多发性骨髓瘤 轻链型淀粉样变性 

分 类 号：R692[医药卫生—泌尿科学]