Nazarov反应构建手性环戊烯酮的研究进展  

Research progress on the construction of chiral cyclopentenone by Nazarov reaction

作　　者：陈致州 CHEN Zhizhou(Intelligent Manufacturing College,Minjiang Teachers college,Fuzhou 350001,China;Double Carbon Smart Energy Technology Research Center,Minjiang Teachers college,Fuzhou 350001,China)

机构地区：[1]闽江师范高等专科学校智能制造学院,福建福州350001 [2]闽江师范高等专科学校双碳智慧能源技术研究中心,福建福州350001

出　　处：《商丘师范学院学报》2024年第12期34-38,共5页Journal of Shangqiu Normal University

基　　金：2022年度福建省中青年教师教育科研项目(JAT220667)。

摘　　要：Nazarov反应大多为酸催化下二乙烯基酮重排成环戊烯酮.手性环戊烯酮因具有独特的结构和多样化的反应位点活性而一直备受有机合成工作者的关注.近几年业界鲜有对此类反应进行综述,为了让从业者们更加透彻了解该研究方向的最新进展,将分为Lewis酸催化、BrФnsted酸催化和其他类型条件三大种类归纳总结2018—2022年以来Nazzarov反应构建手性环戊烯酮的报道,并展望未来研究方向,对进一步研究该类型反应具有重要意义.Nazarov reaction is acid-catalyzed rearrangement of divinyl ketone into cyclopentenone.Chiral cyclopentenone has been attracting the attention of organic synthesis practitioners due to its unique structure and diverse reaction site activity.Considering that there have been few reviews of such reactions recently and in order to allow practitioners to have a more thorough understanding of the progress of this research direction,this article will summarize the reports of Nazzarov reaction to construct chiral cyclopentenone in the past five years,which are divided into three categories:Lewis acid catalysis,Brønsted acid catalysis and other types of conditions.Further research directions will be prospected,which is of great significance for development and research of Nazarov reaction.

关 键 词：Nazarov反应 二乙烯基酮 手性环戊烯酮 路易斯酸 布朗斯特酸 

分 类 号：O62[理学—有机化学]