中药皮肤靶向纳米制剂的研究进展  

Research progress on skin-targeting nano-preparations of traditional Chinese medicine

作　　者：王兆宇 杜茂波[1] 谷丽维[1,2] 刘淑芝 沈硕[1,2] WANG Zhaoyu;DU Maobo;GU Liwei;LIU Shuzhi;SHEN Shuo(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Artemisinin Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]中国中医科学院青蒿素研究中心,北京100700

出　　处：《中草药》2024年第21期7557-7566,共10页Chinese Traditional and Herbal Drugs

基　　金：中国中医科学院科技创新工程项目(CI2021A04307);中国中医科学院优秀青年科技人才(创新类)培养专项(ZZ13-YQ-108);国家中医药管理局项目-中医传统制剂方法(ZZYZK2012);。

摘　　要：皮肤病是全球性的公共卫生问题,严重影响着患者的身心健康。中药在皮肤病治疗方面历史悠久,且中药经皮给药相较其它途径,具有避免首过代谢、药物缓释递送等优势,但部分中药活性成分难以高效透皮直达病灶。而纳米载体技术作为一种先进策略,可增强药物透皮性,实现精准靶向递送,提升治疗效果。重点综述了靶向经皮给药策略的纳米制剂设计原则,纳米药物的结构特点以及纳米靶向经皮给药中药制剂在多种皮肤病治疗中的应用。Skin diseases are a global public health problem,which seriously affect the physical and mental health of patients.Traditional Chinese medicine has a long history in the treatment of skin diseases.Compared with other ways,transdermal administration of traditional Chinese medicine has the advantages of avoiding first-pass metabolism and drug sustained-release delivery,but some active components of traditional Chinese medicine are difficult to penetrate the skin directly to the lesion.As an advanced strategy,nanocarrier technology can enhance the transdermal permeability of drugs,achieve precise targeted delivery,and improve the therapeutic effect.This article focuses on the design principles of nano-preparations for targeted transdermal drug delivery strategies,the structural characteristics of nano-drugs,and the application of nano-targeted transdermal drug delivery traditional Chinese medicine preparations in the treatment of various skin diseases.

关 键 词：皮肤病 中药经皮给药 中药活性成分 纳米载体 纳米靶向制剂 

分 类 号：R28[医药卫生—中药学]