核体在肿瘤中的研究进展  

Research progress of nuclear bodies in tumor

作　　者：刘清远 刘蕴瑶 许义婷 许宇饺 强磊 LIU Qing-yuan;LIU Yun-yao;XU Yi-ting;XU Yu-jiao;QIANG Lei(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 210000,China)

机构地区：[1]中国药科大学基础医学与临床药学学院,江苏南京210000

出　　处：《药学学报》2024年第12期3179-3188,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81974425);江苏省自然科学基金(BK20210419),江苏省自然科学基金资助项目(BK20211578)。

摘　　要：哺乳动物细胞核是高度结构化的,并组织成称为核体的各种无膜核隔室。核体是高度动态的结构,内部聚集着多种物质以促进某些生物反应更加高效地进行,在肿瘤发生、细胞凋亡、抗病毒防御等不同生物学过程和应激条件下动态地产生应答,在调控细胞稳态方面发挥重要的作用。肿瘤作为公共健康的重大问题,寻找新的可用靶点是肿瘤治疗的关键。核体如何参与肿瘤的发生还鲜有报道。本综述以期为核体如何调控肿瘤进展提供新的认识,并为肿瘤的防治提供新的有效策略。The mammalian cell nucleus is highly structured and organized into various membrane-less nuclear compartments called nuclear bodies.Nuclear bodies are highly dynamic structures,with a variety of substances gathered inside to promote the more efficient conduct of certain biological reactions.It dynamically produces responses under different biological processes and stress conditions such as tumorigenesis,apoptosis,antiviral defense,and plays an important role in regulating cell homeostasis.Tumor is a major public health problem,and finding new targets is the key to tumor therapy.How the nuclear bodies are involved in the development of tumor has not been reported.This review aims to provide a new understanding of how the nuclear bodies regulates tumor progression and provide a new effective strategy for tumor prevention and treatment.

关 键 词：核体 核仁 早幼粒细胞白血病核体 核散斑体 旁斑 肿瘤 

分 类 号：R966[医药卫生—药理学]