跨血脑屏障药物载体的研究进展  

Research progress in drug carriers across the blood-brain barrier

作　　者：曹婉昕 杨艺辉 杨红 张森 张宜之 许芳 李婉 郝悦 李晓雪 张旭 杜冠华 王金华 CAO Wan-xin;YANG Yi-hui;YANG Hong;ZHANG Sen;ZHANG Yi-zhi;XU Fang;LI Wan;HAO Yue;LI Xiao-xue;ZHANG Xu;DU Guan-hua;WANG Jin-hua(Key Laboratory of Drug Target Research and Drug Screen,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Shenyang Pharmaceutical University,Shenyang 117004,China)

机构地区：[1]中国医学科学院、北京协和医学院药物研究所,北京市药物靶点研究与新药筛选重点实验室,北京100050 [2]沈阳药科大学,辽宁沈阳117004

出　　处：《药学学报》2024年第12期3222-3231,共10页Acta Pharmaceutica Sinica

基　　金：中国医学科学院创新工程基金(2021-12M-1-029,2023-12M-2-006)。

摘　　要：血脑屏障(blood brain barrier,BBB)在维持大脑内环境稳态的同时,也给中枢神经系统疾病的治疗带来困难。药物载体可以帮助药物穿过血脑屏障发挥药效。本文对药物跨血脑屏障的途径、药物载体入脑后的命运调控及药物载体分类进行了介绍,重点阐述了脂质体、外泌体、凋亡小体、细胞穿透肽和细胞靶向肽的特点及应用,并对跨血脑屏障药物递送领域的研究前景及所面临的挑战进行了分析。The blood-brain barrier(BBB) plays a crucial role in maintaining the homeostasis of the brain's internal environment,which poses challenges to the treatment of central nervous system diseases.Drug carriers can aid in the delivery of therapeutic agents across the BBB to exert their pharmacological effects.The article reviewed the pathways for drug delivery across the BBB,the intracerebral fate and the classification of drug carriers and focuses on the functions and characteristics of liposomes,exosomes,apoptotic bodies,cell-penetrating peptides,and cell-targeting peptides.The review will provide an outlook on the future and challenge of research in the field of drug delivery across the BBB.

关 键 词：药物载体 血脑屏障 脑内命运 脂质体 外泌体 凋亡小体 细胞穿透肽 细胞靶向肽 

分 类 号：R943[医药卫生—药剂学]