T细胞在儿童炎症性肠病中的研究进展  

Progress on T lymphocytes in pediatric inflammatory bowel disease

作　　者：孔琰 张添卓 吴捷 Kong Yan;Zhang Tianzhuo;Wu Jie(Department of Gastroenterology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心、首都医科大学附属北京儿童医院消化科,100045

出　　处：《国际儿科学杂志》2024年第10期649-653,共5页International Journal of Pediatrics

基　　金：国家重点研发计划(2023YFC2706503);北京市卫生健康委员会高层次公共卫生技术人才建设项目培养计划(学科带头人-02-04);深圳市卫生健康委员会深圳市“医疗卫生三名工程”项目资助(SZSM202311023)。

摘　　要：儿童炎症性肠病(pediatric inflammatory bowel disease,PIBD)的发病率在全球范围内呈上升趋势,疾病负担重。尽管对于PIBD的病因学已有一定认识,但具体发病机制仍不明确。近年来,越来越多的研究集中于基因易感性、环境因素及免疫反应的相互作用,其中T细胞发挥关键作用。深入探索PIBD中T细胞的激活、迁移及反应机制,有助于发现潜在的生物标志物及治疗靶点,为早期诊断和患儿个体化管理提供新的思路。该文就T细胞在PIBD发病中的作用、与基因突变的关系以及在临床监测中的应用进行综述,以期提高对PIBD发病机制的理解,为基础研究和临床实践提供参考。The prevalence of pediatric inflammatory bowel disease(PIBD)is on the rise globally,leading to a significant disease burden.While there is some comprehension of PIBD's causes,the precise mechanisms remain uncertain.Recent studies have increasingly focused on the interplay of genetic susceptibility,environmental factors,and immune response,with particular emphasis on the involvement of T lymphocytes.Investigating the activation,migration and response patterns of T lymphocytes in PIBD holds promise for identifying potential biomarkers and therapeutic targets.This exploration could offer fresh insights for early detection and personalized treatment strategies for children with IBD.This article reviews the pivotal role of T lymphocytes in the development of PIBD,their connection to genetic mutations,and their utility in clinical monitoring,in order to enhance the understanding of PIBD's pathogenesis,and provide reference for both basic research and clinical applications.

关 键 词：儿童 T细胞 炎症性肠病 

分 类 号：R725.7[医药卫生—儿科]