儿童鼻窦炎及其对支气管哮喘的影响  

Rhinosinusitis in children and its impact on bronchial asthma

作　　者：耿玉婷 苗瑜 王金荣 冯绛楠 Geng Yuting;Miao Yu;Wang Jinrong;Feng Jiangnan(Pediatric Respiratory Department,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院小儿呼吸科,济南250021

出　　处：《国际儿科学杂志》2024年第10期689-693,共5页International Journal of Pediatrics

基　　金：山东省科技厅科技计划项目(2015GSF118036);山东省自然科学基金(ZR2022MH254)。

摘　　要：哮喘与鼻窦炎都是儿童常见的呼吸系统疾病,具有较高的共患率,两者相互影响,"同一气道、同一疾病"的理论近年来被不断证实。但鼻窦炎常被漏诊,正确识别、及时诊断与治疗鼻窦炎有利于哮喘控制。而鼻窦炎与哮喘都是高度异质性疾病,炎症内型和生物标志物多样且复杂,嗜酸性粒细胞与中性粒细胞均参与其中。该文从鼻窦炎与哮喘共患病的流行病学、鼻窦炎的炎症内型与生物标志物、鼻窦炎对哮喘的影响及其机制、治疗鼻窦炎对哮喘控制的影响进行综述。Asthma and rhinosinusitis are both common respiratory diseases in children,with a high rate of co-morbidity,and both affect each other.The theory of"same airway,same disease"has been confirmed in recent years.However,rhinosinusitis is often underdiagnosed,and correctly recognizing,diagnosing and treating rhinosinusitis in a timely manner is conducive to asthma control.Both rhinosinusitis and asthma are highly heterogeneous diseases,with diverse and complex inflammatory endotypes and biomarkers,including eosinophils and neutrophils.This article reviews the epidemiology of rhinosinusitis and asthma co-morbidities,the inflammatory endotypes and biomarkers of rhinosinusitis,the impact of rhinosinusitis on asthma and its mechanism of influence,and the impact of treating rhinosinusitis on asthma control.

关 键 词：鼻窦炎 哮喘 中性粒细胞 2型炎症 

分 类 号：R765.41[医药卫生—耳鼻咽喉科] R725.6[医药卫生—临床医学]