口腔过敏综合征的诊治进展  

Progress on diagnosis and treatment of oral allergy syndrome

作　　者：刘田玥 王雪艳[1,2] Liu Tianyue;Wang Xueyan(Department of Pediatrics,the Second Hospital of Tianjin Medical University,Tianjin 30021l,China;Pediatric Respiratory and Asthma Research Center,Tianjin Medical University,Tianjin 30021l,China)

机构地区：[1]天津医科大学第二医院儿科,300211 [2]天津医科大学儿童呼吸及哮喘研究中心,300211

出　　处：《国际儿科学杂志》2024年第10期694-698,共5页International Journal of Pediatrics

基　　金：天津市科委基金天津市科技计划项目(22KPHDRC00280)。

摘　　要：口腔过敏综合征(oral allergy syndrome,OAS)也被称为花粉-食物过敏综合征(pollen-food allergy syndrome,PFAS),是一种由吸入性过敏原与食物过敏原交叉反应引起的食物过敏类型。临床表现为摄入食物过敏原后出现如瘙痒、疼痛、麻木等口腔症状,严重者可伴发全身症状。主要的交叉反应性抗原为PR-10家族、脂质转移蛋白、前纤维蛋白和储存蛋白。OAS的诊断主要依据病史、食物激发试验、皮肤点刺试验、抗原特异性IgE检测、变应原组分诊断、嗜碱性粒细胞活化试验等。OAS患者应严格回避过敏性食物,必要时使用抗组胺药物和肾上腺素治疗,生物制剂、特异性免疫治疗、口服耐受诱导疗法也可用于治疗OAS,但疗效仍存在争议。Oral allergy syndrome(OAS),also known as pollen-food allergy syndrome,is a type of food allergy caused by the cross-reaction of inhaled allergens with food allergens.The clinical manifestations are oral symptoms such as itching,pain and numbness after ingestion of food allergens,and systemic symptoms may be accompanied in severe cases.The main cross-reactive antigens are PR-10 family,lipid transfer proteins,prefibrins and storage proteins.The diagnosis of OAS is mainly based on clinical history,oral food challenge,skin prick test,antigen specific IgE detection,allergen component diagnosis,basophil activation test,etc.OAS patients should strictly avoid allergic foods,and use antihistamines and epinephrine when necessary.Biologics,specific immunotherapy,and oral tolerance induction can also be used to treat OAS,but the efficacy is still controversial.

关 键 词：口腔过敏综合征 花粉-食物过敏综合征 食物过敏 交叉过敏反应 

分 类 号：R725.9[医药卫生—儿科]