系统性红斑狼疮合并妊娠母亲对子代健康的影响及相关预测模型的研究进展  

Progress on the influence of pregnant mothers with systemic lupus erythematosus on offsprings health and related prediction models

作　　者：周雅勤 梅花[1] Zhou Yaqin;Mei Hua(Department of Neonatology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学附属医院新生儿科,呼和浩特010000

出　　处：《国际儿科学杂志》2024年第10期710-715,共6页International Journal of Pediatrics

基　　金：内蒙古自治区自然科学基金项目(2020MS08034);内蒙古自治区科学技术厅重点研发和成果转化计划项目(2022YFSH0088);内蒙古自治区卫健委医疗卫生科技计划项目(202201291);内蒙古医科大学青年培育项目(YKD2021QN044)。

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种病因尚不完全明确、产生多种自身抗体并涉及多系统多器官功能障碍的自身免疫性疾病。病情迁延反复,主要影响育龄期女性,可导致多种不良妊娠结局(adverse pregnancy outcomes,APO)。SLE合并妊娠母亲对子代健康的影响主要有胎儿生长受限、早产、小于胎龄儿、新生儿狼疮以及远期健康问题(包括认知、神经或运动发育障碍,过敏性疾病及心血管疾病等不良结局)。通过建立精准的预测模型对SLE合并妊娠APO进行早期预测,及早干预,可最大限度地减少APO,改善对子代健康的近远期影响。该文就SLE合并妊娠母亲对子代健康的影响及相关预测模型的研究进展进行综述。Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by an unclear etiology,the presence of multiple autoantibodies,and dysfunction in various systems and organs.The disease tends to recur and primarily affects women of childbearing age,potentially leading to adverse pregnancy outcomes(APO).The main impacts of SLE on the health of offspring from pregnant mothers include fetal growth restriction,premature birth,small size for gestational age,neonatal lupus,as well as long-term health issues,such as neurocognitive disorders,mental or motor development disorders,allergic diseases,and cardiovascular diseases.By establishing a precise prediction model for APO in SLE combined pregnancies and implementing early interventions accordingly,it is possible to minimize APO occurrences and improve both short-term and long-term effects on offspring health.This article provides a comprehensive review about the effects of SLE on the health of offspring from pregnant mothers along with related prediction models.

关 键 词：系统性红斑狼疮 妊娠 子代 预测模型 

分 类 号：R714.25[医药卫生—妇产科学]