2022—2023年河南省丙型肝炎哨点监测结果  

Sentinel surveillance results for hepatitis C in Henan Province from 2022-2023

作　　者：刘露 李宁[1] 聂玉刚[1] 马彦民[1] 姬晓宇 张国龙 赵东阳[2] LIU Lu;LI Ning;NIE Yugang;MA Yanmin;JI Xiaoyu;ZHANG Guolong;ZHAO Dongyang(Institute for Prevention and Control of STD/AIDS,Henan Center for Disease Control and Prevention,Zhengzhou 450016,China;Henan Center for Disease Control and Prevention)

机构地区：[1]河南省疾病预防控制中心性病艾滋病防治研究所,郑州450016 [2]河南省疾病预防控制中心

出　　处：《现代疾病预防控制》2024年第12期894-897,共4页MODERN DISEASE CONTROL AND PREVENTION

摘　　要：目的监测河南省丙型肝炎(丙肝)哨点不同人群丙肝病毒(HCV)感染情况,为评估丙肝的流行趋势和评价防控效果提供依据。方法收集2022—2023年河南省丙肝哨点监测数据(分为丙肝人群哨点和医院哨点),分析不同监测人群基本特征、丙肝抗体(抗-HCV)阳性率、HCV核酸阳性率和抗病毒治疗比例。结果2022—2023年河南省丙肝人群哨点监测覆盖了血液透析人群、无偿献血人群、HIV感染者、医院侵入性诊疗人群和单位体检人群5类人群。单位体检人群中未发现抗-HCV阳性者,其他4类人群总抗-HCV阳性率为0.89%(92/10353);其中,HIV感染者和医院侵入性诊疗人群抗-HCV阳性率较高(χ^(2)=91.82,P<0.001),分别为1.92%和1.72%。丙肝医院哨点监测抗-HCV阳性率为1.34%(4726/353965),感染科/传染科是抗-HCV阳性率(7.45%,454/6090)和HCV核酸阳性率(50.64%,275/543)最高的送检科室。新报告HCV感染病例的HCV核酸检测率为57.21%,抗病毒治疗比例为35.79%。结论HIV感染者和医院侵入性诊疗人群是河南省丙肝防治的重点人群,感染科/传染科是医疗机构中发现丙肝病例的重点科室,新报告HCV感染病例的核酸检测率和抗病毒治疗比例需进一步提升。应加强重点人群、重点科室的HCV筛查检测,同时强化丙肝确诊病例的抗病毒治疗工作,以达到消除丙肝公共卫生危害的目标。Objective To understand the prevalence of hepatitis C virus(HCV)infection in different populations in Henan Province during 2022-2023,so as to provide evidence for the estimation of trend of hepatitis C prevalence and evaluation on the prevention and control effect.Methods Data from HCV sentinel surveillance(including HCV population sentinel sites and hospital sentinel sites)in Henan from 2022-2023 were collected;the population general characteristics,positive rate of antiHCV antibodies(anti-HCV),positive rate of HCV nucleic acid and the proportion of antiviral treatment among different surveillance populations were analyzed.Results From 2022 to 2023,the sentinel surveillance of hepatitis C population in Henan covered five groups:hemodialysis population,unpaid blood donor population,population with human immunodeficiency virus(HIV)infection,hospital invasive diagnosis and treatment population,and physical examination population of employment.In the physical examination population of employment,none of persons with positive anti-HCV were found.The overall positive rate of anti-HCV in the other four groups was 0.89%(92/10353),and the positive rates of anti-HCV in the HIV-infected population and the hospital-invasive diagnosis and treatment population were 1.92%and 1.72%,respectively,higher than those in the other groups(χ^(2)=91.82,P<0.001).The positive rate of anti-HCV in the sentinel hospital surveillance was 1.34%(4726/353965).The samples from department of infectious/communicable diseases had the highest positive rates of anti-HCV(7.45%,454/6090)and HCV nucleic acid(50.64%,275/543)in the medical institutions.The newly reported anti-HCV positive cases had a HCV nucleic acid test rate of 57.21%and a antiviral treatment rate of 35.79%.Conclusions HIV-infected patients and hospitalinvasive patients are the key population for the prevention and treatment of hepatitis C in Henan.The department of infectious/communicable diseases is a key department for identifying cases of hepatitis C in healthcare institutions;the

关 键 词：丙型肝炎 哨点监测 丙型肝炎抗体 防治进展 

分 类 号：R512.6[医药卫生—内科学]