2018—2023年广东省珠海市人感染猪链球菌病流行病学和临床特征分析  

Epidemiological and clinical characteristics of human infection with Streptococcus suis in Zhuhai City of Guangdong Province,2018-2023

作　　者：萧松建[1] 周奕[2] XIAO Songjian;ZHOU Yi(Zhuhai Center for Disease Control and Prevention,Zhuhai,Guangdong 519000,China;The Affiliated Fifth Hospital of ZhongshanUniversity)

机构地区：[1]珠海市疾病预防控制中心,广东珠海519000 [2]中山大学附属第五医院

出　　处：《现代疾病预防控制》2024年第12期927-930,共4页MODERN DISEASE CONTROL AND PREVENTION

基　　金：珠海市社会发展领域科技计划项目(2220004000158)。

摘　　要：目的分析珠海市人感染猪链球菌病流行病学特征和临床特征,为人感染猪链球菌病疫情防控提供科学依据。方法根据《全国人感染猪链球菌病监测方案》(2009版),对2018—2023年珠海市报告的人感染猪链球菌病例开展流行病学调查,采集病例的血液或脑脊液标本开展细菌培养、生化鉴定、Maldi-Tof-MS快速鉴定和血清分型,采用描述性分析方法,对人感染猪链球菌病例的流行病学和临床特征进行分析。结果2018—2023年珠海市累计报告人感染猪链球菌病病例11例,其中,男性10例,女性1例,男女比例10∶1;年龄在25~73岁之间,6—9月发病数9例,占81.8%;9例(81.8%)与职业无关。暴露方式有猪肉食用加工4例(36.4%)、猪肉进食4例(36.4%)、生猪屠宰2例(18.2%)、原因不明1例(9.1%);暴露前口腔粘膜破损4例(36.4%)、手部有伤口3例(27.3%)。发病到初诊、发病到入院、发病到确诊、发病到出院时间中位数分别为0.5 d、1.0 d、3.0 d、10.0 d。临床症状主要为发热100.0%、咳嗽45.5%、呕吐45.5%、头痛45.5%、关节肿痛45.5%、听力减退36.4%等。实验室检查结果显示,白细胞升高8例(72.7%),脑脊液检查异常4例(100.0%),血清分型主要为猪链球菌2型9例(81.8%)、14型2例(18.2%)。临床分型:普通型4例(36.4%)、脑膜炎型4例(36.4%)、中毒性休克型3例(27.3%)。预后痊愈6例(54.5%)、永久性耳聋4例(36.4%)、死亡1例(9.1%)。结论人感染猪链球菌病严重危害人类健康,应完善联防联控机制,加强医务人员培训和诊疗意识,加强大众卫生健康知识宣传。Objective To provide scientific evidence for prevention and control of human infection with Streptococcus suis(SS)through analyzing the epidemiological and clinical characteristics of human infection with SS in Zhuhai.Methods According to the National Surveillance Protocol for Human Infection with SS(2009 edition),epidemiological investigation of human infection with SS reported in Zhuhai from 2018 to 2023 was carried out.Blood or cerebrospinal fluid samples were collected from the infected cases for bacterial culture,biochemical identification,rapid identification by Maldi-Tof-MS,and serotyping.Descriptive analysis was used to analyze the epidemiological and clinical characteristics of human infection with SS.Results A total of 11 cases of human infection with SS were reported in Zhuhai from 2018 to 2023.Of them,nine were male,and one was female,and male to female ratio was 10∶1.The ages of them were between 25-73 years.Nine cases(81.8%)were reported between June and September.Nine cases(81.8%)were not related to occupation.The exposure modes included pork processing in four cases(36.4%),pork eating in four cases(36.4%),pig slaughtering in two cases(18.2%),and unknown cause in one case(9.1%).Oral mucosa was injured in four cases(36.4%)and hand wound in 3 cases(27.3%)before exposure.The median durations from onset to first diagnosis,admission,confirmed diagnosis and discharge were 0.5 days,1.0 days,3.0 days,and 10.0days,respectively.Clinical symptoms included fever(100.0%),cough(45.5%),vomiting(45.5%),headache(45.5%),arthralgia(45.5%),and hearing loss(36.4%).Eight cases(72.7%)showed elevated white blood cell levels,and four cases(100.0%)had abnormal cerebrospinal fluid results.The main serotypes of SS were type 2,including nine cases(81.8%),and type 14,including two cases(18.2%).Clinical classification:general type including four cases(36.4%),meningitis type including four cases(36.4%),and toxic shock type including three cases(27.3%).About the prognosis,six cases(54.5%)were cured,four cases(36.4%)were permanen

关 键 词：猪链球菌 流行病学 临床特征 珠海市 

分 类 号：R183.9[医药卫生—流行病学]