2011—2022年福建省输入性登革热病例流行特征及时间聚集性分析  

Epidemic characteristics and time aggregation analysis of imported dengue in Fujian Province,2011—2022

作　　者：詹美蓉[1] 蔡少健[1] 黄峥强[1] 谢忠杭[1] 陈武[1] 欧剑鸣[1] ZHAN Meirong;CAI Shaojian;HUANG Zhengqiang;XIE Zhonghang;CHEN Wu;OU Jianming(Fujian Provincial Center for Disease Control and Prevention,Fuzhou,Fujian 350012,China)

机构地区：[1]福建省疾病预防控制中心,福建福州350012

出　　处：《中国预防医学杂志》2024年第9期1152-1156,共5页Chinese Preventive Medicine

基　　金：2021年福建省卫生健康科技计划项目(2021GGB010)。

摘　　要：目的 分析2011—2022年福建省登革热输入病例的时空特点、输入来源特征及流行规律,为制定相应的预防控制措施提供参考。方法 对2011—2022年福建省输入性登革热个案信息进行整理,分析病例的输入来源、时间聚集性及疾病的三间分布等流行特征。发病与诊断时间间隔的比较采用非参数H检验,时间聚集性分析采用动态窗口时间扫描统计量分析。结果 2011—2022年福建省共报告登革热病例3 387例,各地市均有输入性病例共1 146例,境内输入57例,1 089例境外输入病例来源于28个国家和地区,主要为东南亚;男女性别比为3.36∶1,发病以18~<60岁为主1 036例(95.13%);职业分布前三位的为家务及待业311例(28.56%)、农民214例(19.65%)和商业服务人员213例(19.56%);6—10月为主要时间聚集段,对数似然比(log-likelihood ratio,LLR)为163.1,相对危险度(relative risk,RR)为3.09 (P=0.001)。355例为入境前发病,615例为入境后发病。发病与诊断时间间隔平均为4.83 d,在发病的病毒血症期(发病5 d)内。结论 福建省常年存在登革热输入风险,且易引起本土暴发流行,应采取更加科学的防控措施控制登革热的输入与本地流行。Objective To investigate the spatio-temporal distribution the characteristics of imported sources,and the epidemiological pattern of imported dengue outbreaks in Fujian Province, 2011—2022, and to provide a reference for formulating corresponding prevention and control measures. Methods The data of imported dengue cases in Fujian Province from 2011 to 2022 were sorted out, and the epidemic characteristics of imported cases were analyzed, such as the source of the cases, the time aggregation, and the tripartite distribution of the disease. A nonparametric H test was used for the comparison of onset and diagnosis time intervals, and dynamic window time sweep statistics were used for time clustering analysis. Results From 2011 to 2022, there were 3 387 reported cases of dengue fever in Fujian Province, a total of 1 146 imported cases in various regions, with 57 cases within the country and 1 089 cases from abroaol originating from 28countries and regions, mainly from Southeast Asia. The number of male cases was 3. 36 times higher than female cases, and the disease was mainly prevalent between 18 and <60 years of age people(1 036 cases,95. 13%). The top three occupations were housework and unemployment(311 cases, 28. 56%), farmers(214 cases, 19. 65%), and commercial services personnel(213 cases, 19. 56%). The main time clustering period was between June and October, with a log-likelihood ratio(LLR) of 163. 1 and a relative risk(RR) of 3. 09(P=0. 001). Among the 970 cases with available information,355 cases occurred before entry into China,and 615 cases occurred after entry. The average time interval between onset and diagnosis was 4. 83 d during the viremia period(5 d of onset). Conclusions Fujian Province is at risk of imported dengue fever throughout the year and is prone to local outbreaks. In order to control the importation and local epidemic of dengue,more scientific prevention and control measures should be taken.

关 键 词：登革热 输入性 时间聚集性 流行特征 

分 类 号：R183.5[医药卫生—流行病学]