基于“阴阳自和”理论探析中医药对肿瘤免疫微环境及其免疫细胞的调控作用  

Exploring regulation of tumor immune microenvironment and immune cells by traditional Chinese medicine based on theory of"yin‑yang self‑harmony"

作　　者：李娜娜 马祯慧 张颖[1] 王琳璇 张玉新 李洪霖 LI Nana;MA Zhenhui;ZHANG Ying;WANG Linxuan;ZHANG Yuxin;LI Honglin(The Second Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou,Henan 450002,China;Department of Oncology,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou,Henan 450003,China)

机构地区：[1]河南中医药大学第二临床医学院,河南郑州450002 [2]河南省中医院肿瘤科,河南郑州450003

出　　处：《上海中医药杂志》2024年第12期22-27,共6页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81804057);河南省中医药管理局河南省中医药科学研究专项课题(2022ZY2018)。

摘　　要：肿瘤免疫微环境(TIME)中存在大量免疫细胞,包括肿瘤相关中性粒细胞(TANs)、肿瘤相关巨噬细胞(TAMs)、调节性T细胞(Treg)和树突状细胞(DCs)等,正常生理状态下人体的免疫细胞维持着动态平衡,在机体免疫应答、免疫维持方面发挥着重要作用。肿瘤免疫治疗即靶向TIME的免疫抑制细胞,使人体自身免疫系统恢复其免疫原性。不论是机体正常的免疫应答机制,还是现代肿瘤免疫治疗机制都与中医“阴阳自和”理论高度相似。探究肿瘤免疫细胞失衡与中医“阴阳自和”的相关性,可为阴阳理论指导下的中医药调控免疫细胞恢复免疫循环提供新思路。The tumor immune microenvironment(TIME)contains numerous immune cells,including tumor-associated neutrophils(TANs),tumorassociated macrophages(TAMs),regulatory T cells(Tregs),and dendritic cells(DCs).Under normal physiological conditions,the human body's immune cells maintain a dynamic balance,playing a critical role in immune responses and homeostasis.Tumor immunotherapy targets the immunosuppressive cells within the TIME to restore the immune system's immunogenicity.Both the body's natural immune response and the mechanisms behind modern tumor immunotherapy share significant parallels with the traditional Chinese medicine(TCM)theory of"yin-yang selfharmony".Investigating the correlation between immune cell imbalance in tumors and the"yin-yang self-harmony"theory in TCM offers a new perspective on how TCM can regulate immune cells to restore immune balance and circulation based on the guidance of yin-yang theory.

关 键 词：肿瘤微环境 免疫调控 阴阳自和 中医理论 中医药疗法 

分 类 号：R273[医药卫生—中西医结合]