基于“肝肾同源”理论探讨补肝益肾法对膝骨关节炎内质网应激的调节作用  

Study on regulatory effect of nourishing liver and kidneys method on endoplasmic reticulum stress in knee osteoarthritis based on theory of"liver and kidneys sharing same source"

作　　者：杜蜀徽 黄传兵[2,3] 夏艳楠 吴爱红 陈小涵 徐佳敏 DU Shuhui;HUANG Chuanbing;XIA Yannan;WU Aihong;CHEN Xiaohan;XU Jiamin(First Clinical Medical College,Anhui University of Chinese Medicine,Hefei,Anhui 230038,China;Department ofRheumatology,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,Anhui 230031,China;Xin'an Institute of Medicine and Modernization of Traditional Chinese Medicine,The First Affiliated Hospital of AnhuiUniversity of Chinese Medicine,Hefei,Anhui 230031,China)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230038 [2]安徽中医药大学第一附属医院风湿科,安徽合肥230031 [3]安徽中医药大学第一附属医院新安医学与中医药现代化研究所,安徽合肥230031

出　　处：《上海中医药杂志》2024年第12期47-51,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81473672);合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所科研项目(2023CXMMTCM004,2023CXMMTCM015);安徽省教育厅2022年度新时代育人质量工程项目(2022tsxwd038);安徽省中医药管理局2022年度省级中医优势(特色)专科建设项目(皖中医药服务秘[2022]34号)。

摘　　要：膝骨关节炎(KOA)是一种慢性骨关节疾病,过度和长期的内质网应激可导致软骨细胞凋亡,靶向内质网应激可以延缓KOA进展。“肝肾同源”理论认为,肝与肾都源于生殖之精,在生理、病理上关系密切,肝主筋、肾主骨,肝肾亏虚是KOA的关键病机。肝肾功能(中医学概念)与内质网功能具有相似性,补肝益肾类中药可通过调控内质网应激介导的关键通路干扰关键物质合成,从而减少内质网应激的发生,最终起到延缓KOA进展的作用。Knee osteoarthritis(KOA)is a chronic bone and joint disease.Excessive and prolonged endoplasmic reticulum(ER)stress can lead to chondrocyte apoptosis.Targeting ER stress may delay the progression of KOA.According to the theory of"liver and kidneys sharing the same source",both organs derive from reproductive essence and are closely related physiologically and pathologically.The liver governs tendons,while the kidneys govern bones,making deficiency of liver and kidneys a critical pathogenesis of KOA.The functions of the liver and kidneys(from a traditional Chinese medicine perspective)show similarities to ER function.Traditional Chinese herbal medicines that nourish the liver and kidneys can modulate key pathways involved in ER stress,interfering with the synthesis of critical substances,thereby reducing the incidence of ER stress and ultimately delaying the progression of KOA.

关 键 词：膝骨关节炎 内质网应激 肝肾同源 中医药疗法 

分 类 号：R274.9[医药卫生—中西医结合]