中医药调控自然杀伤细胞防治肺癌转移的研究进展  

Research progress on regulation of NK cells by traditional Chinese medicine in prevention and treatment of lung cancer metastasis

作　　者：王衍鸿 田建辉[1,2] 罗斌[1,2] 杨蕴[1,2] 阙祖俊 WANG Yanhong;TIAN Jianhui;LUO Bin;YANG Yun;QUE Zujun(Clinical Oncology Center,Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai Universityof Traditional Chinese Medicine,Shanghai 200071,China;Institute of Oncology,Shanghai Municipal Hospital ofTraditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院肿瘤临床医学中心,上海200071 [2]上海中医药大学附属市中医医院肿瘤研究所,上海200071

出　　处：《上海中医药杂志》2024年第12期170-178,共9页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82174245,82104943,81973517);上海市卫健委卫生健康领军人才项目(2022LJ014),上海市卫健委进一步加快中医药传承创新发展三年行动计划项目(ZY[2021-2023]-0211);上海市科委炎癌转化病证生物学前沿研究基地项目(2021科技03-12)。

摘　　要：综述固有免疫紊乱与肺癌转移的关系,自然杀伤(NK)细胞的肿瘤免疫机制,以及靶向NK细胞防治肺癌转移的临床应用策略。中药单体、中药复方以及中医外治方法通过多层次、多途径和多靶点的作用机制,可有效调节免疫功能,抑制肿瘤细胞的增殖与转移。The review covers the relationship between innate immune dysregulation and lung cancer metastasis,the tumor immune mechanisms of natural killer(NK)cells,and the clinical application strategies of NK cells in preventing and treating lung cancer metastasis.Traditional Chinese medicine(TCM)components,including TCM monomers,compound formulas,and external therapies,regulate immune function through multilayered,multi-pathway,and multi-target mechanisms,effectively inhibiting the proliferation and metastasis of tumor cells.

关 键 词：肺癌 肿瘤转移 自然杀伤细胞 固有免疫 免疫治疗 中医药疗法 

分 类 号：R273[医药卫生—中西医结合]