沙格列汀联合格列美脲治疗2型糖尿病合并肥胖患者的效果  

Effects of Saxagliptin combined with Glimepiride in treatment of type 2 diabetes mellitus complicated with obesity

作　　者：华海霞[1] HUA Haixia(Department of Internal Medicine of Jiangyin Fifth Hospital,Wuxi 214407 Jiangsu,China)

机构地区：[1]江阴市第五人民医院内科,江苏无锡214407

出　　处：《中国民康医学》2024年第23期21-23,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察沙格列汀联合格列美脲治疗2型糖尿病合并肥胖患者的效果。方法:回顾性分析2021—2022年该院收治的60例2型糖尿病合并肥胖患者的临床资料,按照治疗方法不同将其分为对照组和观察组各30例。两组均进行基础治疗和饮食、运动指导,在此基础上,对照组采用格列美脲治疗,观察组在对照组基础上联合沙格列汀治疗,两组均连续治疗3个月。比较两组临床疗效,治疗前后血糖指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)]、胰岛功能指标[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]、体质量指数(BMI)水平,以及不良反应发生率。结果:观察组治疗总有效率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);治疗后,观察组FPG、2hPG、HbA1c、FINS、HOMA-IR水平低于对照组,HOMA-β水平高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组BMI水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:沙格列汀联合格列美脲治疗2型糖尿病合并肥胖患者可提高治疗总有效率,改善血糖指标、胰岛功能指标水平,降低BMI水平,效果优于单纯格列美脲治疗。Objective:To observe effects of Saxagliptin combined with Glimepiride in treatment of type 2 diabetes mellitus with obesity.Methods:The clinical data of 60 patients with type 2 diabetes mellitus complicated with obesity admitted to this hospital from 2021 to 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,30 cases in each group.Both groups were given basic treatment and diet and exercise guidance.On this basis,the control group was treated with Glimepiride,while the observation group was treated with Saxagliptin on the basis of that of the control group.Both groups were treated continuously for 3 months.The clinical efficacy,the levels of blood glucose indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],islet function indexes[fasting insulin(FINS),insulin resistance index(HOMA-IR),isletβcell function index(HOMA-β)]and body mass index(BMI)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.67%(29/30),which was higher than 73.33%(22/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FPG,2hPG,HbA1c,FINS and HOMA-IR in the observation group were lower than those in the control group,the level of HOMA-βwas higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the BMI level of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Saxagliptin combined with Glimepiride in the treatment of type 2 diabetes mellitus with obesity can improve the total effective rate of treatment,improve the levels of blood glucose indexes and islet function indexes,and red

关 键 词：2型糖尿病 肥胖 沙格列汀 格列美脲 血糖 胰岛功能 体质量指数 

分 类 号：R587.1[医药卫生—内分泌]