托法替布联合氨甲蝶呤治疗类风湿关节炎患者的效果  

Effects of Tofacitinib combined with Methotrexate in treatment of patients with rheumatoid arthritis

作　　者：牛玲玲 NIU Lingling(Department of Rheumatism and Pain of the Second People’s Hospital of Anyang,Anyang 455000 Henan,China)

机构地区：[1]安阳市第二人民医院风湿疼痛科,河南安阳455000

出　　处：《中国民康医学》2024年第23期31-34,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察托法替布联合氨甲蝶呤治疗类风湿关节炎患者的效果。方法:回顾性分析2021年4月至2023年4月该院收治的88例类风湿关节炎患者的临床资料,按照治疗方法不同将其分为对照组和观察组各44例。对照组给予甲氨蝶呤片治疗,观察组在对照组基础上联合枸橼酸托法替布片治疗。比较两组临床疗效,治疗前后疼痛程度[视觉模拟评分法(VAS)]评分、疾病活动度[28个关节肿胀数和压痛数表(DAS28)]评分、炎性因子[γ干扰素(IFN-γ)、白细胞介素-6(IL-6)、白细胞介素-35(IL-35)、白细胞介素-17(IL-17)]水平、疾病特异性指标[可溶性细胞间黏附分子-1(sICAM-1)、血管生成素样蛋白2(Angptl2)]水平,以及不良反应发生率。结果:观察组治疗总有效率为100.00%(44/44),高于对照组的86.36%(38/44),差异有统计学意义(P<0.05);两组VAS、DAS28评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IFN-γ、IL-6、IL-17水平均低于治疗前,且观察组低于对照组,两组IL-35水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组sICAM-1、Angptl2水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:托法替布联合氨甲蝶呤治疗类风湿关节炎患者可提高治疗总有效率,改善炎性因子水平,以及降低疼痛程度评分、疾病活动度评分和疾病特异性指标水平的效果优于单纯氨甲蝶呤治疗。Objective:To observe effects of Tofacitinib combined with Methotrexate in treatment of patients with rheumatoid arthritis.Methods:The clinical data of 88 patients with rheumatoid arthritis admitted to this hospital from April 2021 to April 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,44 cases in each group.The control group was treated with Methotrexate tablets,while the observation group was treated with Tofacitinib citrate tablets on the basis of that of the control group.The clinical efficacy,the pain degree[visual analogue scale(VAS)]score,the disease activity[disease activity score(DAS28)]score,the inflammatory factors[interferon-γ(IFN-γ),interleukin-6(IL-6),interleukin-35(IL-35),interleukin-17(IL-17)]levels,the disease-specific indexes[soluble intercellular adhesion molecule-1(sICAM-1),angiopoietin-like protein 2(Angptl2)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 100.00%(44/44),which was higher than 86.36%(38/44)in the control group,and the difference was statistically significant(P<0.05).The VAS and DAS28 scores of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IFN-γ,IL-6 and IL-17 in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of IL-35 in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).The levels of sICAM-1 and Angptl2 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group

关 键 词：托法替布 氨甲蝶呤 类风湿关节炎 疾病活动度 炎性因子 疼痛程度 不良反应 

分 类 号：R593.22[医药卫生—内科学]